Research on neuronal functions of the synaptic protein GIT1 = 시냅스 단백질 GIT1의 neuronal function에 관한 연구

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GIT1 is a synaptic scaffolding protein that interacts with various pre- and postsynaptic proteins, and is expressed in various brain regions. To investigate in vivo functions of GIT1, we have generated GIT1 knockout mice using genetrap. Immunoblot analysis revealed that expression levels of βPix, a binding partner of GIT1, were reduced in GIT1 mutant mice. Electrophysiological data showed that the basal synaptic transmission was increased and LTP was reduced in GIT1-/- mice. In behavioral analyses, GIT1-/- mice showed enhanced locomotor activity and lowered anxiety. In addition, GIT1-/- mice showed impaired motor coordination and motor learn. Lastly, spatial learning was impaired in GIT1-/- mice. These results indicate GIT1 is an important regulator of synaptic plasticity, anxiety, and spatial and motor learning.
Advisors
Kim, Eun-Joonresearcher김은준researcher
Description
한국과학기술원 : 생명과학과,
Publisher
한국과학기술원
Issue Date
2008
Identifier
310388/325007  / 020068042
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명과학과, 2008.2, [ iv, 46 p. ]

Keywords

GIT1; synaptic protein; behavioral analysis; electrophysiology; 시냅스 단백질; 동물 행동실험 분석; 전기생리학 분석; GIT1; synaptic protein; behavioral analysis; electrophysiology; 시냅스 단백질; 동물 행동실험 분석; 전기생리학 분석

URI
http://hdl.handle.net/10203/28107
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=310388&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
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