Epigenetic approach for reconfiguring gene regulatory network = 유전자 전사 조절 네트워크를 재분석하는 후성유전학적 접근 방법

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Gene expression is a coordinated work of whole processes of gene regulation. To conquer gene expression completely, there are many ways to describe and understand this phenomena. Inferring gene regulatory network is most well known and powerful approach to configurate the process of gene regulation. However, the increasing study about epigenetics shows that not only the genetic mechanism but also epigenetic mechanism, such as DNA methylation, histone modification, chromatin remodeling, etc are significantly influencing the gene regulation. Such foundation leads us to deeper understanding of gene regulation in the view point of epigenetics. In this study, we attempt to find the relation between the gene regulatory network and epigenetic states analyzing histone modification data. We used well known network model, ARACNE, which is based on information theoretic approach to obtain direct interaction between genes. To analyze the epigenetic states of each nodes in the regulatory network, we use the histone modification data from the Yeast chromatin database, Chrom DB.
Advisors
Yoo, Ook-Joonresearcher유욱준researcher
Description
한국과학기술원 : 생명과학과,
Publisher
한국과학기술원
Issue Date
2008
Identifier
301930/325007  / 020068035
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명과학과, 2008. 8., [ iv, 26 p. ]

Keywords

Epigenetics; gene; regulatory; network; histone; 후성유전학; 유전자; 조절; 네트워크; 히스톤; Epigenetics; gene; regulatory; network; histone; 후성유전학; 유전자; 조절; 네트워크; 히스톤

URI
http://hdl.handle.net/10203/28105
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=301930&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
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