DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Chung, Jong-kyeong | - |
dc.contributor.advisor | 정종경 | - |
dc.contributor.author | Jang, Chol-soon | - |
dc.contributor.author | 장철순 | - |
dc.date.accessioned | 2011-12-12T08:55:05Z | - |
dc.date.available | 2011-12-12T08:55:05Z | - |
dc.date.issued | 2006 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=301302&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/28101 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 생명과학과, 2006.2, [ vii, 57 p. ] | - |
dc.description.abstract | LKB1 is a serine/threonine kinase that functions as a master tumor suppressor in the small intestine. Although numerous molecular and biochemical studies have implicated LKB1 in a variety function of cellular processes, little is known about the tumor suppressing mechanism of LKB1 in vivo. Therefore, I performed genetic modifier screening in Drosophila to discover the novel proteins involved in tumor suppressor LKB1 signaling pathway in vivo. Subsequently, I identified Silnoon (Sln) as a novel LKB1-interacting gene, which is a monocarboxylate transporter (MCT) mediating the influx of extra-cellular butyrate. Surprisingly, Sln induces ectopic apoptosis, which is enhanced by co-expression of LKB1 as well as butyrate treatment. In contrast, downregulation of Sln suppressed LKB1-dependent apoptosis and caused a drastic brain hyperplasia phenotype as observed in the LKB1-null mutant. Moreover, ectopic expression of Sln was sufficient to suppress the brain hyperplasia phenotype of LKB1-null mutant, demonstrating that Sln is a downstream effector of the LKB1 signaling pathway. Finally, I showed that LKB1 kinase activity affects the subcellular localization of Sln during eye morphogenesis. Since some monocarboxylate transporters are involved in the cancer development as a tumor, I suggest a plausible synapse between the two tumor suppressing mechanisms, LKB1 and MCT, which however were known be unlinked. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | tumor suppressor LKB1 | - |
dc.subject | 항암 유전자 엘케이비1 | - |
dc.title | Characterization of tumor suppressor LKB1 signaling pathway in vivo | - |
dc.title.alternative | 항암 유전자 LKB1 신호 전달계의 생체 내 기능 연구 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 301302/325007 | - |
dc.description.department | 한국과학기술원 : 생명과학과, | - |
dc.identifier.uid | 020043516 | - |
dc.contributor.localauthor | Chung, Jong-kyeong | - |
dc.contributor.localauthor | 정종경 | - |
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