Tip60 represses transcriptional activity of NF-κB = Tip60의 NF-κB 전사활성 억제

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Tip60, a cellular protein with intrinsic histone acetyltransferase activity, plays an important role in DNA damage repair and apoptosis. Recent studies have suggested that Tip60 acts either as a transcriptional coactivator or corepressor. Daxx, a protein binding with various factors involved in cell death regulation, was found to interact with Tip60. The interaction between Tip60 and Daxx through the HAT domain was confirmed by coimmunoprecipitation. Luciferase reporter gene assay and chromatin immunoprecipitation assay reveal that Tip60 and Daxx repress the transcriptional activity of NF-κB. In this report, we suggest that Tip60 is a corepressor of the NF-κB-mediated transcriptinal activity in part through the recruitment of Daxx to promoters of NF-κB responsive genes.
Advisors
Joe, Cheol-O.researcher조철오researcher
Description
한국과학기술원 : 생명과학과,
Publisher
한국과학기술원
Issue Date
2007
Identifier
264269/325007  / 020053594
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명과학과, 2007.2, [ vi, 39 p. ]

Keywords

NF-κB; Daxx; Tip60; transcriptional activity; 전사활성; NF-κB; Daxx; Tip60

URI
http://hdl.handle.net/10203/28091
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=264269&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
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