Roles of ARF6 and EFA6A in the development and maintenance of dendritic spinesARF6와 EFA6A에 의한 Spine 형성과 유지에 관한 연구

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dc.contributor.advisorKim, Eun-Joon-
dc.contributor.advisor김은준-
dc.contributor.authorChoi, Seung-Won-
dc.contributor.author최승원-
dc.date.accessioned2011-12-12T08:54:39Z-
dc.date.available2011-12-12T08:54:39Z-
dc.date.issued2006-
dc.identifier.urihttp://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=255235&flag=dissertation-
dc.identifier.urihttp://hdl.handle.net/10203/28072-
dc.description학위논문(석사) - 한국과학기술원 : 생명과학과, 2006.2, [ iv, 53 p. ]-
dc.description.abstractThe cellular and molecular mechanisms underlying the development and maintenance of dendritic spines are not fully understood. ARF6 is a small GTPase known to regulate actin remodeling and membrane traffic. I studied involvement of ARF6 and EFA6A, an ARF6-specific exchange factor, in the regulation of spine development and maintenance. An active form of ARF6 promotes the formation of dendritic spines at the expense of filopodia. EFA6A promotes spine formation in an ARF6 activation-dependent manner. Knockdown of ARF6 and EFA6A by siRNA decreases spine formation. Live imaging indicates that ARF6 knockdown decreases the conversion of filopodia to spines and the stability of early spines. The spine promoting effect of ARF6 is partially blocked by Rae 1. ARF6 and EFA6A protect mature spines from inactivity-induced destabilization. These results suggest that ARF6 and EFA6A may regulate the conversion of filopodia to spines and the stability of both early and mature spines.eng
dc.languageeng-
dc.publisher한국과학기술원-
dc.subjectfilopodia-
dc.subjectSpine-
dc.subjectARF6-
dc.subject시냅스-
dc.subject스파인-
dc.subjectRac1-
dc.subjectEFA6A-
dc.titleRoles of ARF6 and EFA6A in the development and maintenance of dendritic spines-
dc.title.alternativeARF6와 EFA6A에 의한 Spine 형성과 유지에 관한 연구-
dc.typeThesis(Master)-
dc.identifier.CNRN255235/325007 -
dc.description.department한국과학기술원 : 생명과학과, -
dc.identifier.uid020043620-
dc.contributor.localauthorKim, Eun-Joon-
dc.contributor.localauthor김은준-
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BS-Theses_Master(석사논문)
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