Notch represses p63 transactivation = Notch에 의한 p63의 전사활성 억제

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 286
  • Download : 0
Aberrant Notch signaling contributes to more than half of all human T-cell leukemias. Accumulating evidence indicates Notch involvement in other human neoplasms. To investigate the possible role of Notch in the regulation of p63, one of the p53 family proteins, which induces the expression of several target proteins involved in cell cycle arrest and apoptosis, I examined the effect of Notch signaling on the transactivation functions of p63. Ectopic expression of activated human Notchl (Nl-IC) represses p63 transactivation. Data show that p63 protein levels are reduced by the expression of N1-IC in HCT116 p53-/- cells. Data further suggest that proteasomedependent degradation of protein did not result in the decrease of p63 protein levels by Nl-IC. The transactivation of NI-IC is attributable to the decrease of p63 protein levels since Notchl-ARAM mutant which lacks the ability of Nl-IC to transactivate its target genes did not reduce levels of p63 protein. I showed that Notchl suppresses transcription of p63 in RT-PCR analysis. Therefore, this study concludes that Nl-IC mediates suppression of p63 transactivation by inhibiting transcription of p63.
Advisors
Joe, Cheol-Oresearcher조철오researcher
Description
한국과학기술원 : 생명과학과,
Publisher
한국과학기술원
Issue Date
2006
Identifier
255228/325007  / 020043254
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명과학과, 2006.2, [ v, 46 p. ]

Keywords

Notch; p63; p63; Notch

URI
http://hdl.handle.net/10203/28065
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=255228&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0