혈압 파형 재현을 위한 심혈관계 시뮬레이터

Abstract

The cardiovascular simulator designed in this study can reproduce blood pressure waveforms based on human cardiovascular physiology. The proposed simulator consists of three main modules: heart, artery, and reservoir, and is designed to reproduce human cardiovascular behavior, especially blood pressure waveforms. The heart module reproduces the ventricular input pressure applied to the entire system through stroke control. The arterial module follows the physiology of the human body's cardiovascular system and can be adjusted with a resistance valve that adjusts the open area of the blood vessel and a compliance chamber that adjusts the wall stiffness of the ascending aorta. The simulator was cross-validated by comparing the fluid-electric analogue model, known as the windkessel model, and human body data. As a result, the ventricular and aortic pressure waveforms measured by the simulator matched well with the realistic human blood pressure waveform. To analyze the correlation between cardiovascular physiology and blood pressure waveforms, a parametric study of peripheral resistance and aortic compliance was performed. The designed simulator is based on cardiovascular physiology, so it is possible to reproduce realistic human blood pressure waveforms in a controllable manner by adjusting the structural parameters of the components. This platform is applicable to blood pressure sensor calibration and parameter analysis of blood pressure waveforms.