Optogenetic inhibition of medial entorhinal cortex inputs to the hippocampus during a short period of time right after learning disrupts contextual fear memory formation

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dc.contributor.authorKang, Min Sooko
dc.contributor.authorHan, Jin-Heeko
dc.date.accessioned2021-02-08T02:10:06Z-
dc.date.available2021-02-08T02:10:06Z-
dc.date.created2021-02-03-
dc.date.issued2021-01-
dc.identifier.citationMOLECULAR BRAIN, v.14, no.1-
dc.identifier.issn1756-6606-
dc.identifier.urihttp://hdl.handle.net/10203/280634-
dc.description.abstractFormation of temporal association memory and context-specific fear memory is thought to require medial entorhinal cortex (MEC) inputs to the hippocampus during learning events. However, whether the MEC inputs are also involved in memory formation during a post-learning period has not been directly tested yet. To examine this possibility, we optogenetically inhibited axons and terminals originating from bilateral dorsal MEC excitatory neurons in the dorsal hippocampus for 5 min right after contextual fear conditioning (CFC). Mice expressing eNpHR3.0 exhibited significantly less freezing compared to control mice expressing EGFP alone during retrieval test in the conditioned context 1 day after learning. In contrast, the same optogenetic inhibition of MEC inputs performed 30 min before retrieval test did not affect freezing during retrieval test, excluding the possibility of non-specific deleterious effect of optical inhibition on retrieval process. These results support that contextual fear memory formation requires MEC inputs to the hippocampus during a post-learning period.-
dc.languageEnglish-
dc.publisherBMC-
dc.titleOptogenetic inhibition of medial entorhinal cortex inputs to the hippocampus during a short period of time right after learning disrupts contextual fear memory formation-
dc.typeArticle-
dc.identifier.wosid000608119400001-
dc.identifier.scopusid2-s2.0-85098783674-
dc.type.rimsART-
dc.citation.volume14-
dc.citation.issue1-
dc.citation.publicationnameMOLECULAR BRAIN-
dc.identifier.doi10.1186/s13041-020-00719-w-
dc.contributor.localauthorHan, Jin-Hee-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorMedial entorhinal cortex-
dc.subject.keywordAuthorHippocampus-
dc.subject.keywordAuthorContextual fear conditioning-

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