Regulation of MMP-9 protein expression level in response to treatment of iron chelator, desferrioxamine = Iron Chelator desferrioxamine에 의한 MMP-9 단백질 발현조절에 관한 연구

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Metastasis is main cause of death in cancer patients. Active matrix metalloproteinases (MMPs) play a critical role in tumor invasion and metastasis. Many studies have shown that reactive oxygen species (ROS) increase the expression level and activation of MMPs through mitogen-activating protein kinase (MAPK) signaling pathway. In a cell, hydrogen peroxide, a kind of ROS, is metabolized hydroxyl radical by intracellular iron ions. Treatment of iron chelator desferrioxamine (DFO) co-treated with PMS for sustained hydrogen peroxide generation accumulates intracellular hydrogen peroxide that induces the up-regulation of MMP-9. The MMP-9 expression is activated through p38 MAPK signaling pathway. The phosphorylation of p38 MAPK is increased as the intracellular hydrogen peroxide accumulated. Phosphorylated p38 MAPK increases the translocation of NF-κB into a nucleus. Inhibition of p38 MAPK signaling pathway decreases the NF-κB translocation. And inhibition of NF-κB activation reduces the MMP-9 expression level. So, it is found that DFO-PMS co-treatment accumulates intracellular hydrogen peroxide that activate the MMP-9 expression level through p38/NF-κB pathway.
Advisors
Chung, An-Sik정안식
Description
한국과학기술원 : 생명과학과,
Publisher
한국과학기술원
Issue Date
2005
Identifier
243531/325007  / 020033601
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명과학과, 2005.2, [ v, 47 p. ]

Keywords

DEAE Chromatography; Sialyltransferase; estrogen receptor osyltransferase; MMP-9 ROS DFO p38 NF-kB oactivator-1; 2-D HPLCnjugation; DEAE 크로마토그래피; 시알산 전이효소; SPOP 전이효소; 에스트로겐 수용체; MMP-9 활성산소종 DFO p38 NF-kB

URI
http://hdl.handle.net/10203/28056
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=243531&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
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