Polyacrylonitrile-based carbon nanofibers as a matrix for laser desorption/ionization time-of-flight mass spectrometric analysis of small molecules under both positive and negative ionization modes

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Carbon fiber (CNF), prepared by carbonization of electrospun polyacrylonitrile (PAN) fibers, is systematically investigated as a mediator to replace conventional organic matrices for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-MS). CNF exhibits a high salt tolerance, sensitivity, and resolution for organic matrix-free laser desorption/ionization time-of-flight mass spectrometry (LDI-MS) analysis of various analytes under both positive and negative ionization modes. Especially, saccharides, a neutral molecule having low negative ionization efficiency, are successfully detected with CNF. Taken together, this study clearly demonstrates CNF is a promising material to develop an efficient and universal platform for LDI-MS analysis regardless of preferential ionization modes of analytes.
Publisher
SPRINGER HEIDELBERG
Issue Date
2021-02
Language
English
Article Type
Article
Citation

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v.413, no.4, pp.1193 - 1202

ISSN
1618-2642
DOI
10.1007/s00216-020-03083-9
URI
http://hdl.handle.net/10203/280455
Appears in Collection
CBE-Journal Papers(저널논문)
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