DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Chung, Jae-Hoon | - |
dc.contributor.advisor | 정재훈 | - |
dc.contributor.author | Yang, Jin-Hee | - |
dc.contributor.author | 양진희 | - |
dc.date.accessioned | 2011-12-12T08:54:05Z | - |
dc.date.available | 2011-12-12T08:54:05Z | - |
dc.date.issued | 2004 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=240340&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/28035 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 생명과학과, 2004, [ iv, 54 p. ] | - |
dc.description.abstract | The post synaptic density (PSD) is a postsynaptic membrane specialization at neuronal synapses. The PSD undergoes dynamic structural changes and protein turnover during synaptic maturation and plasticity. A key mechanism controlling protein turnover is the ubiquitin-proteasome pathway. Here I identified Dorfin, a RING finger-type E3 ubiquitin ligase, as a binding partner of PSD-95, an abundant PSD component that is important for synaptic structure and plasticity. The C terminus of Dorfin interacts with the PDZ domains of PSD-95. Dorfin selectively binds to the PSD-95 family proteins as shown in yeast two-hybrid, coimmunoprecipitation and coclustering assays. Dorfin selectively ubiquitinates PSD-95 and other PSD-95 family proteins. These results suggest that Dorfin, through the degradation of PSD-95 family proteins, contributes to the structural and functional plasticity of synapses. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | DORFIN | - |
dc.subject | E3 UBIQUITIN LIGASE | - |
dc.subject | PSD-95 | - |
dc.subject | PSD-95 분해 | - |
dc.subject | Dorfin | - |
dc.subject | E3 ubiquitin 연결 효소 | - |
dc.subject | DEGRADATION | - |
dc.title | Role of the E3 ubiquitin ligase dorfin in the degradation of PSD-95 family proteins | - |
dc.title.alternative | E3 ubiquitin ligase dorfin에 의한 PSD-95 분해에 관한 연구 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 240340/325007 | - |
dc.description.department | 한국과학기술원 : 생명과학과, | - |
dc.identifier.uid | 020023931 | - |
dc.contributor.localauthor | Chung, Jae-Hoon | - |
dc.contributor.localauthor | 정재훈 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.