Regulation of FOXO transcription factor = FOXO 전사 인자의 조절

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It is well known that the FOXO subfamily of forkhead transcription factors play a critical role in cell cycle, apoptosis, and energy metabolism, and are important for mediating effects of insulin and growth factors on gene expression as a downstream target of phosphatidylinositol 3-kinase (PI3K) and Akt. Here, I found a novel regulator of FOXO transcription factor, CRK, through genetic screening. Through coimmunoprecipitation analyses, I demonstrated that FKHR directly interacts with CRK in vivo, and that the C-terminal of CRK is needed for interaction with FKHR. Furthermore, I examined the regulation of CRK on FKHR; I revealed that CRK phosphorylates and thus, inhibits FKHR-dependent transcription in a kinase-activity-dependent manner, and that CRK induces the nuclear exclusion of FKHR by export mechanism using immunocytochemical analyses. Collectively, these findings establish CRK as a new regulator of FKHR.
Advisors
Chung, Jong-Kyeongresearcher정종경researcher
Description
한국과학기술원 : 생명과학과,
Publisher
한국과학기술원
Issue Date
2004
Identifier
237822/325007  / 020023489
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명과학과, 2004.2, [ iv, 53 p. ]

Keywords

PI3K SIGNALING PATHWAY; FOXO TRANSCRIPTION FACTOR; AKT; Akt 인산화 효소; PI3K 신호 전달; FOXO 전사 인자

URI
http://hdl.handle.net/10203/28029
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=237822&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
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