Photo-crosslinked, temperature-sensitive, and biodegradable pluronic hydrogels for sustained and controlled delivery of bioactive macromoelcules = 생리활성 거대분자 약물들의 서방형 제어 방출을 위한 광중합된 온도민감성 생분해성 플루로닉 하이드로젤에 관한 연구

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 212
  • Download : 0
Thermally sensitive and biodegradable hydrogels based on Pluronic tri-block copolymers were prepared by a photo-polymerization method. Two terminal hydroxyl groups in Pluronic F-127 were acrylated to form a Pluronic macromer. Photo-crosslinked Pluronic hydrogels prepared by UV irradiation showed a gradually decreased swelling ratio with increasing temperature, and exhibited thermally responsive change in the swelling ratio when the temperature was cycled between 10℃ and 37℃. These Pluronic hydrogels degraded slowly due to the cleavage of ester linkage in the acrylated Pluronic terminal end. When lysozyme, a model protein drug, was loaded in the hydrogels, bi-phasic protein release profiles were attained: a burst-free and rapid controlled release profile was initially observed for a one week period and a much slower sustained release was followed thereafter. Released lysozyme from Pluronic hydrogel was almost identical to native one, indicating that UV irradiation wuth short time and low intensity did not significantly affect the conformation of lysozyme. The release rates could be controlled by varying the amount of Pluronic macromer for photo-polymerization. And, Poly(lactic-co-glycolic acid) (PLGA) microspheres were physically entrapped within the Pluronic hydrogel in order to modulate local pH environment by acidic degradation by-products of PLGA microspheres. The PLGA microspheres were slowly degraded to create an acidic micro-environment, which facilitated the cleavage of an acid-labile ester-linkage in the biodegradable Pluronic hydrogel network. The presence of PLGA microspheres accelerated the degradation of the Pluronic hydrogel and enhanced protein release rate when Bovine serum albumin(BSA), a model protein drug, was loaded in the Pluronic hydrogel.
Advisors
Park, Tae-Gwanresearcher박태관researcher
Description
한국과학기술원 : 생명과학과,
Publisher
한국과학기술원
Issue Date
2004
Identifier
237820/325007  / 020023483
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명과학과, 2004.2, [ vi, 51 p. ]

Keywords

DRUG DELIVERY SYSTEM; PHOTO-CROSSLINKED HYDROGEL; BIODEGRADATION; 생분해성; 약물전달시스템; 광중합된 하이드로젤

URI
http://hdl.handle.net/10203/28027
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=237820&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0