DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Chung, Jong-Kyeong | - |
dc.contributor.advisor | 정종경 | - |
dc.contributor.author | Lee, Eun-Ji | - |
dc.contributor.author | 이은지 | - |
dc.date.accessioned | 2011-12-12T08:53:57Z | - |
dc.date.available | 2011-12-12T08:53:57Z | - |
dc.date.issued | 2004 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=237819&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/28026 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 생명과학과, 2004.2, [ iv, 46 p ] | - |
dc.description.abstract | Parkin, encoding E3 ubiquitin-ligase is linked to Autosomal Recessive Juvenile Parkinsonism (AR-JP). The locomotive defects in Parkinson’s disease patients are known to be due to the selective loss of dopaminergic (DA) neurons. Here, I generated P-element inserted Dparkin null flies with abnormal wing posture and lower climbing ability. Intriguingly, I observed apoptotic phenotypes in Dparkin mutant indirect flight muscle (IFM), including mitochondrial swelling and TUNEL- positive nuclei. Dparkin mutant also showed elaborate branching of motor neurons on IFM. Using GAL4 system, I showed that Dparkin deficiency in DA neurons was responsible for IFM apoptosis. Meanwhile, elaborate neuronal branching, which was alleviated by pan-neuronal expression of exogenous Parkin, failed to be restored by either DA neuronal or muscle expression of exogenous Parkin. Moreover, Dparkin mutant showed reduced pre-synaptic vesicle protein (CSP)-positive signals on IFM, suggesting that Dparkin has a neuronal growth regulatory role at the neuro muscular junction (NMJ) by affecting synaptic transmission. Collectively, I demonstrate that Dparkin has essential roles in both muscle cell survival and motor neuronal branching control, strongly supporting the importance of Parkin in neurodegenerative movement disorder of Parkinson’s disease. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | PARKIN | - |
dc.subject | DROSOPHILA | - |
dc.subject | 초파리 | - |
dc.subject | 파킨 | - |
dc.title | Characterization of drosophila parkin in vivo | - |
dc.title.alternative | 초파리 파킨 유전자의 기능 연구 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 237819/325007 | - |
dc.description.department | 한국과학기술원 : 생명과학과, | - |
dc.identifier.uid | 020023461 | - |
dc.contributor.localauthor | Chung, Jong-Kyeong | - |
dc.contributor.localauthor | 정종경 | - |
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