Regulation of MMP-2 activity in response to treatment of $PPAR_γ$ agonists = $PPAR_γ$ agonists에 의한 MMP-2 활성 조절에 관한 연구

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Metastasis is the main cause of death in cancer patients. Active matrix metalloproteinases (MMPs) play a key role in tumor invasion. Many studied have tried to examine the role of peroxisome proliferator-activated receptor γ (PPARγ) in cancer. But it is still a debatable issue. Here, we report for the first time that ciglitazone induced pro-MMP-2 activation through induction of memebrane type 1-MMP (MT1-MMP) expression and increased the invasiveness of tumor in HT1080 cell but not the other PPARγ agonists of thiazolidinedione (TZD) class. Ciglitazone activated strongly PPAR_γ. But MMP-2 activation was not relevant to PPAR_γ activation. To investigate the mechanism of MMP-2 activation by ciglitazone, various antioxidants and signal inhibitors are pre-treated. So, we find that ciglitazone induced pro-MMP-2 activation by the sustained production of $H_2O_2$. And it was also regulated by ERK/NF-κB pathway.
Advisors
Chung, An-Sik정안식
Description
한국과학기술원 : 생명과학과,
Publisher
한국과학기술원
Issue Date
2004
Identifier
237805/325007  / 020023042
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명과학과, 2004.2, [ vi, 49 p. ]

Keywords

MMP-2 ACTIVITY; 활성 조절; PPARG AGONIST

URI
http://hdl.handle.net/10203/28012
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=237805&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
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