Dexamethasone releasing biodegradable polymer scaffolds fabricated by a gas foaming/salt leaching method = 항염증 약물 서방형 다공성 생분해성 고분자 지지체에 관한 연구

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Dexamethasone, a steroidal anti-inflammatory drug, was incorporated into porous biodegradable polymer scaffolds for sustained release. The slowly released dexamethasone from the degrading scaffolds was hypothesized to locally modulate the proliferation and differentiation of various cells. Dexamethasone containing porous poly(D,L-lactic-co-glycolic acid) [PLGA] scaffolds were fabricated by a gas foaming/salt leaching method. Dexamethasone was loaded within the polymer phase of the PLGA scaffold in a molecularly dissolved state. The loading efficiency of dexamethasone varied from 57 % to 65 % depending on the initial loading amount. Dexamethasone was slowly released out in a controlled manner over 30 days without showing the initial burst release. Release amount and release duration could be adjusted by controlling the initial loading amount within the scaffolds. Released dexamethasone from the scaffolds drastically suppressed the proliferations of lymphocytes and smooth muscle cells in vitro. This study suggests that dexamethasone releasing PLGA scaffolds could be potentially used as either an anti-inflammatory porous prosthetic device or temporal biodegradable stents for reducing intimal hyperplasia in restenosis.
Advisors
Kim, Hak-Sungresearcher김학성researcher
Description
한국과학기술원 : 생물과학과,
Publisher
한국과학기술원
Issue Date
2002
Identifier
177023/325007 / 020003252
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생물과학과, 2002.8, [ iii, 25 p. ]

Keywords

PLGA; scaffolds; dexamethasone; lymphocyte; 항염증; 고분자 지지체; 덱사메타존; smooth muscle cell

URI
http://hdl.handle.net/10203/27975
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=177023&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
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