Drosophila PDZ-GEF a novel component of the MAP kinase signaling pathway = 초파리 PDZ-GEF에 의한 MAP kinase 신호전달계의 조절

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PDZ-GEF is a novel family of guanine nucleotide exchange factor for Rap1. Here I isolated Drosophila PDZ-GEF (dPDZ-GEF) which contains the all the conserved domains of mammalian and nematode PDZ-GEF including cNMP-binding, Ras exchange motif, PDZ, RA, and GEF domains. dPDZ-GEF loss-of-function mutants were defective in the development of various organs including eye, wing and ovaries, and this phenotype is strikingly similar to the phenotype of rolled mutant, implying that dPDZ-GEF functions upstream of the MAPK pathway. Indeed, we found that dPDZ-GEF is specifically involved in photoreceptor cell differentiation, facilitating its neuronal fate via activation of the MAPK pathway. Rap1 was found to link dPDZ-GEF to the MAPK pathway; however, Ras was not involved in the regulation of the MAPK pathway by dPDZ-GEF, and actually had an inhibitory function. Collectively, our findings identify dPDZ-GEF as a novel upstream regulator of the MAPK signaling pathway, and demonstrate the presence of a novel, Ras-independent mechanism for activating the MAPK signaling pathway.
Advisors
Chung, Jong-Kyeongresearcher정종경researcher
Description
한국과학기술원 : 생물과학과,
Publisher
한국과학기술원
Issue Date
2002
Identifier
173567/325007 / 020003431
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생물과학과, 2002.2, [ iv, 47 p. ]

Keywords

Ras; PDZ-GEF; Drosophila; MAPK; 광수용체; 신호전달; 초파리; photoreceptor

URI
http://hdl.handle.net/10203/27965
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=173567&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
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