Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer

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dc.contributor.authorLee, Hae-Ockko
dc.contributor.authorHong, Youraeko
dc.contributor.authorEtlioglu, Hakki Emreko
dc.contributor.authorCho, Yong Beomko
dc.contributor.authorPomelle, Valentinako
dc.contributor.authorVan den Bosch, Benko
dc.contributor.authorVanhecke, Jasperko
dc.contributor.authorVerbandt, Sarako
dc.contributor.authorHong, Hyekyungko
dc.contributor.authorMin, Jae-Woongko
dc.contributor.authorKim, Nayoungko
dc.contributor.authorEum, Hye Hyeonko
dc.contributor.authorQian, Junbinko
dc.contributor.authorBoeckx, Bramko
dc.contributor.authorLambrechts, Dietherko
dc.contributor.authorTsantoulis, Petrosko
dc.contributor.authorDe Hertogh, Gertko
dc.contributor.authorChung, Woosungko
dc.contributor.authorLee, Taeseobko
dc.contributor.authorAn, Minaeko
dc.contributor.authorShin, Hyun-Taeko
dc.contributor.authorJoung, Je-Gunko
dc.contributor.authorJung, Min-Hyeokko
dc.contributor.authorKo, Gunhwanko
dc.contributor.authorWirapati, Pratyakshako
dc.contributor.authorKim, Seok Hyungko
dc.contributor.authorKim, Hee Cheolko
dc.contributor.authorYun, Seong Hyeonko
dc.contributor.authorTan, Iain Bee Huatko
dc.contributor.authorRanjan, Bobbyko
dc.contributor.authorLee, Woo Yongko
dc.contributor.authorKim, Tae-Youko
dc.contributor.authorChoi, Jung Kyoonko
dc.contributor.authorKim, Young-Joonko
dc.contributor.authorPrabhakar, Shyamko
dc.contributor.authorTejpar, Sabineko
dc.contributor.authorPark, Woong-Yangko
dc.date.accessioned2021-01-05T16:50:14Z-
dc.date.available2021-01-05T16:50:14Z-
dc.date.created2020-06-01-
dc.date.issued2020-06-
dc.identifier.citationNATURE GENETICS, v.52, no.6, pp.594 - +-
dc.identifier.issn1061-4036-
dc.identifier.urihttp://hdl.handle.net/10203/279565-
dc.description.abstractSingle-cell RNA sequencing of colorectal tumors highlights associations between lineage-related gene expression signatures and specific stromal and immune cell populations. Immunotherapy for metastatic colorectal cancer is effective only for mismatch repair-deficient tumors with high microsatellite instability that demonstrate immune infiltration, suggesting that tumor cells can determine their immune microenvironment. To understand this cross-talk, we analyzed the transcriptome of 91,103 unsorted single cells from 23 Korean and 6 Belgian patients. Cancer cells displayed transcriptional features reminiscent of normal differentiation programs, and genetic alterations that apparently fostered immunosuppressive microenvironments directed by regulatory T cells, myofibroblasts and myeloid cells. Intercellular network reconstruction supported the association between cancer cell signatures and specific stromal or immune cell populations. Our collective view of the cellular landscape and intercellular interactions in colorectal cancer provide mechanistic information for the design of efficient immuno-oncology treatment strategies.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleLineage-dependent gene expression programs influence the immune landscape of colorectal cancer-
dc.typeArticle-
dc.identifier.wosid000535394900003-
dc.identifier.scopusid2-s2.0-85085343999-
dc.type.rimsART-
dc.citation.volume52-
dc.citation.issue6-
dc.citation.beginningpage594-
dc.citation.endingpage+-
dc.citation.publicationnameNATURE GENETICS-
dc.identifier.doi10.1038/s41588-020-0636-z-
dc.contributor.localauthorChoi, Jung Kyoon-
dc.contributor.nonIdAuthorLee, Hae-Ock-
dc.contributor.nonIdAuthorHong, Yourae-
dc.contributor.nonIdAuthorEtlioglu, Hakki Emre-
dc.contributor.nonIdAuthorCho, Yong Beom-
dc.contributor.nonIdAuthorPomelle, Valentina-
dc.contributor.nonIdAuthorVan den Bosch, Ben-
dc.contributor.nonIdAuthorVanhecke, Jasper-
dc.contributor.nonIdAuthorVerbandt, Sara-
dc.contributor.nonIdAuthorHong, Hyekyung-
dc.contributor.nonIdAuthorMin, Jae-Woong-
dc.contributor.nonIdAuthorKim, Nayoung-
dc.contributor.nonIdAuthorEum, Hye Hyeon-
dc.contributor.nonIdAuthorQian, Junbin-
dc.contributor.nonIdAuthorBoeckx, Bram-
dc.contributor.nonIdAuthorLambrechts, Diether-
dc.contributor.nonIdAuthorTsantoulis, Petros-
dc.contributor.nonIdAuthorDe Hertogh, Gert-
dc.contributor.nonIdAuthorChung, Woosung-
dc.contributor.nonIdAuthorLee, Taeseob-
dc.contributor.nonIdAuthorAn, Minae-
dc.contributor.nonIdAuthorShin, Hyun-Tae-
dc.contributor.nonIdAuthorJoung, Je-Gun-
dc.contributor.nonIdAuthorJung, Min-Hyeok-
dc.contributor.nonIdAuthorKo, Gunhwan-
dc.contributor.nonIdAuthorWirapati, Pratyaksha-
dc.contributor.nonIdAuthorKim, Seok Hyung-
dc.contributor.nonIdAuthorKim, Hee Cheol-
dc.contributor.nonIdAuthorYun, Seong Hyeon-
dc.contributor.nonIdAuthorTan, Iain Bee Huat-
dc.contributor.nonIdAuthorRanjan, Bobby-
dc.contributor.nonIdAuthorLee, Woo Yong-
dc.contributor.nonIdAuthorKim, Tae-You-
dc.contributor.nonIdAuthorKim, Young-Joon-
dc.contributor.nonIdAuthorPrabhakar, Shyam-
dc.contributor.nonIdAuthorTejpar, Sabine-
dc.contributor.nonIdAuthorPark, Woong-Yang-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusCONSENSUS MOLECULAR SUBTYPES-
dc.subject.keywordPlusCOLON-CANCER-
dc.subject.keywordPlusT-CELLS-
dc.subject.keywordPlusHETEROGENEITY-
dc.subject.keywordPlusCLASSIFICATION-
dc.subject.keywordPlusANGIOGENESIS-
dc.subject.keywordPlusOSTEOPONTIN-
dc.subject.keywordPlusREGULATOR-
dc.subject.keywordPlusPHENOTYPE-
dc.subject.keywordPlusPERICYTES-
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