Temperature-responsive and degradable hyaluronic acid/pluronic composite hydrogels for controlled release of human growth hormone = 인간성장호르몬의 제어 방출을 위한 온도민감성과 분해성을 가진 하이루론산/ 플루로닉 조성의 하이드로젤에 관한 연구

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Temperature-sensitive hyaluronic acid (HA) hydrogels were synthesized by photopolymerization of vinyl group modified HA in combination with acrylate group end-capped poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) tri-block copolymer (Pluronic F127). The synthesized HA/Pluronic composite hydrogels gradually collapsed with increasing temperature over the range of 5-40℃, suggesting that the Pluronic component formed self associating micelles in the hydrogel structure. Upon prolonged incubation in a buffer medium, the micelles slowly degraded due to the hydrolytic scission of the ester linkage between the Pluronic and acrylate group. The mass erosion occurred much faster at 37℃ than at 13℃, indicating that at the higher temperature, the ester linkage between the Pluronic and acrylate group might be more exposed to an aqueous environment and thus be more readily hydrolyzed due to Pluronic micellization. Incorporation of recombinant human growth hormone in the hydrogel resulted in a sustained release profile which followed a mass erosion pattern.
Advisors
Kim, Hak-Sungresearcher김학성researcher
Description
한국과학기술원 : 생물과학과,
Publisher
한국과학기술원
Issue Date
2002
Identifier
173551/325007 / 020003066
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생물과학과, 2002.2, [ v, 39 p. ]

Keywords

degradation; Pluronic; hyaluronic acid; temperature-sensitive; 온도민감성; 분해; 플루로닉; 히아루론산

URI
http://hdl.handle.net/10203/27949
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=173551&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
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