Methods for treating Parkinson`s disease파킨슨 증상을 치료하는 방법

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The present invention relates to a method for treating Parkinson's disease. According to this method, a halorhodopsin protein, a polynucleotide encoding the halorhodopsin protein or a vector containing the polynucleotide above is introduced into ventrolateral thalamus (VL) or medial globus pallidus (GPm) neurons of a subject having Parkinson's disease. The VL neurons are then illuminated with green light or exposed to a T type Ca2+ channel blocker to inhibit rebound firing of VL neurons. By inhibiting rebound firing of VL neurons, Parkinson's disease can be treated or prevented.
Assignee
KAIST
Country
US (United States)
Application Date
2018-04-25
Application Number
15962894
Registration Date
2020-12-01
Registration Number
10849990
URI
http://hdl.handle.net/10203/279366
Appears in Collection
BS-Patent(특허)
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