Serotonin Regulates De Novo Lipogenesis in Adipose Tissues through Serotonin Receptor 2A

Cited 5 time in webofscience Cited 0 time in scopus
  • Hit : 67
  • Download : 29
Background: Obesity is defined as excessive fat mass and is a major cause of many chronic diseases such as diabetes, cardiovascular disease, and cancer. Increasing energy expenditure and regulating adipose tissue metabolism are important targets for the treatment of obesity. Serotonin (5-hydroxytryptophan [5-HT]) is a monoamine metabolite of the essential amino acid tryptophan. Here, we demonstrated that 5-HT in mature adipocytes regulated energy expenditure and lipid metabolism. Methods: Tiyptophan hydroxylase 1 (TPH1) is the rate-limiting enzyme during 5-HT synthesis in non-neural peripheral tissues. We generated adipose tissue-specific Tph1 knockout (Tph1 FKO) mice and adipose tissue-specific serotonin receptor 2A KO (Htr2a FKO) mice and analyzed their phenotypes during high-fat diet (HFD) induced obesity. Results: Tph1 FKO mice fed HFD exhibited reduced lipid accumulation, increased thermogenesis, and resistance to obesity. In addition Htr2a FKO mice fed HFD showed reduced lipid accumulation in white adipose tissue and resistance to obesity. Conclusion: These data suggest that the inhibition of serotonin signaling might be an effective strategy in obesity.
Publisher
KOREAN ENDOCRINE SOC
Issue Date
2020-06
Language
English
Article Type
Article
Citation

ENDOCRINOLOGY AND METABOLISM, v.35, no.2, pp.470 - 479

ISSN
2093-596X
DOI
10.3803/EnM.2020.35.2.470
URI
http://hdl.handle.net/10203/279331
Appears in Collection
MSE-Journal Papers(저널논문)
Files in This Item
000596724000028.pdf(1.86 MB)Download
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 5 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0