(The) antioxidant effect of Pinus maritima extract (Pycnogenol) and Ulmus macrocarpa extract = Pinus maritima Extract (Pycnogenol)와 Ulmus macrocarpa Extract에 의한 항산화 효과

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In this study, we investigated the antioxidant activity of $Pycnogenol^®$ and Ulmus macrocarpa extract. $Pycnogenol^®$ is proprietary extract of the bark of the French maritime pine tree (Pinus maritime). The Extracts from the bark of pine have been used in the past in different parts of the world in traditional medicine and are believed to affect various pathologies raging from vascular disease to arthritis. Ulmus macrocarpa is a deciduous tree which is distributed in Asia-temperate regions and the stem and root bark have been used in oriental traditional medicine for treatment of oedema, mastitis, gastric cancer and inflammation. Both Pycnogenol and Ulmus macrocarpa extract inhibited the deoxyribose degradation by hydroxyl radical and also inhibited NBT reduction by superoxide anion in vitro. But both didn``t scavenge hydrogen peroxide. Both $Pycnogenol^®$ and Ulmus macrocarpa extract protected the single-strand breaks in the plasmid DNA by Fe(II) and H2O2, and also by xanthine oxidase /hypoxanthine. But $Pycnogenol^®$ protected only up to 25㎍/ml whereas over 25㎍/ml of this showed the prooxidant activity. $Pycnogenol^®$ and Ulmus macrocarpa extract inhibited Fe(II) autooxidation and increased the Fe(III) reduction. $Pycnogenol^®$ showed more stronger prooxidant activity converting Fe(III) to Fe(II) than Ulmus macrocarpa extract. We also observed $Pycnogenol^®$ and Ulmus macrocarpa extract could protect the isolated plasmid DNA through chelating Fe(II) ions.
Advisors
Chung, An-Sik정안식
Description
한국과학기술원 : 생물과학과,
Publisher
한국과학기술원
Issue Date
2000
Identifier
158703/325007 / 000983370
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생물과학과, 2000.2, [ viii, 49 p. ]

Keywords

Antioxidant; Ulmus macrocarpa; Pycnogenol; Chelation; 항산화제; 왕느릅나무; 해송; Prooxidant

URI
http://hdl.handle.net/10203/27903
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=158703&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
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