Interaction of viral interferon regulatory factor 1 of Kaposi's Sarcoma associated Herpesvirus and CREB binding protein = 카포시 육종 헤르페스바이러스의 인터페론 조절인자와 CREB binding protein의 상호작용에 관한 연구

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Kaposi``s sarcoma-associated herpesvirus (KSHV) contains many cellular homologue genes, in addition to genes required for viral replication and assembly. The K9 open reading frame (ORF) of KSHV encodes a virus-encoded interferon regulatory factor (vIRF) which functions as a repressor for cellular interferon-mediated signal transduction, and as an oncogene to induce cell growth transformation. In addition, KSHV vIRF plays an important role in regulation gene expression. From genetic and biochemical analysis, we demonstrate that KSHV vIRF1 binds to a transcriptional coactivator CREB-binding protein (CBP) in vivo and in vitro. CBP plays a central role in the regulation of gene expression and is the target for several viral proteins such as adenovirus E1A, SV40 large T, and human papillomavirus E6. KSHV vIRF1 binds to the KIX domain and CH/3 region of CBP. The CH/3 region of CBP coinsides with the binding region of adenovirus E1A. We also show that vIRF1 inhibits the transactivational activity of CBP in HeLa cells. These results demonstrate that vIRF1 can modulate gene expression by inhibiting the transactivation function of coactivator CBP.
Advisors
Choe, Joon-Horesearcher최준호researcher
Description
한국과학기술원 : 생물과학과,
Publisher
한국과학기술원
Issue Date
2000
Identifier
158699/325007 / 000983271
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생물과학과, 2000.2, [ ii, 51 p. ]

Keywords

CREB binding protein; Kaposi``s Sarcoma associated herpesvirus; Interferon regulatory factor; 인터페론조절인자; CREB binding protein; 카포시육종 바이러스

URI
http://hdl.handle.net/10203/27899
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=158699&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
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