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College of Life Science and Bioengineering(생명과학기술대학)Graduate School of Medical Science & Engineering(의과학대학원)MSE-Journal Papers(저널논문)

Decoding human fetal liver haematopoiesis

Cited 317 time in webofscience Cited 203 time in scopus
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dc.contributor.authorPopescu, Dorin-Mirelko
dc.contributor.authorBotting, Rachel A.ko
dc.contributor.authorStephenson, Emilyko
dc.contributor.authorGreen, Kileko
dc.contributor.authorWebb, Simoneko
dc.contributor.authorJardine, Laurako
dc.contributor.authorCalderbank, Emily F.ko
dc.contributor.authorPolanski, Krzysztofko
dc.contributor.authorGoh, Issacko
dc.contributor.authorEfremova, Mirjanako
dc.contributor.authorAcres, Meghanko
dc.contributor.authorMaunder, Danielko
dc.contributor.authorVegh, Peterko
dc.contributor.authorGitton, Yorickko
dc.contributor.authorPark, Jong-Eunko
dc.contributor.authorVento-Tormo, Roserko
dc.contributor.authorMiao, Zhichaoko
dc.contributor.authorDixon, Davidko
dc.contributor.authorRowell, Rachelko
dc.contributor.authorMcDonald, Davidko
dc.contributor.authorFletcher, Jamesko
dc.contributor.authorPoyner, Elizabethko
dc.contributor.authorReynolds, Garyko
dc.contributor.authorMather, Michaelko
dc.contributor.authorMoldovan, Corinako
dc.contributor.authorMamanova, Lirako
dc.contributor.authorGreig, Frankieko
dc.contributor.authorYoung, Matthew D.ko
dc.contributor.authorMeyer, Kerstin B.ko
dc.contributor.authorLisgo, Stevenko
dc.contributor.authorBacardit, Jaumeko
dc.contributor.authorFuller, Andrewko
dc.contributor.authorMillar, Benko
dc.contributor.authorInnes, Barbarako
dc.contributor.authorLindsay, Susanko
dc.contributor.authorStubbington, Michael J. T.ko
dc.contributor.authorKowalczyk, Monika S.ko
dc.contributor.authorLi, Boko
dc.contributor.authorAshenberg, Orrko
dc.contributor.authorTabaka, Marcinko
dc.contributor.authorDionne, Danielleko
dc.contributor.authorTickle, Timothy L.ko
dc.contributor.authorSlyper, Michalko
dc.contributor.authorRozenblatt-Rosen, Oritko
dc.contributor.authorFilby, Andrewko
dc.contributor.authorCarey, Peterko
dc.contributor.authorVillani, Alexandra-Chloeko
dc.contributor.authorRoy, Aninditako
dc.contributor.authorRegev, Avivko
dc.contributor.authorChedotal, Alainko
dc.contributor.authorRoberts, Ireneko
dc.contributor.authorGottgens, Bertholdko
dc.contributor.authorBehjati, Samko
dc.contributor.authorLaurenti, Elisako
dc.contributor.authorTeichmann, Sarah A.ko
dc.contributor.authorHaniffa, Muzlifahko
dc.date.accessioned2020-12-04T02:30:11Z-
dc.date.available2020-12-04T02:30:11Z-
dc.date.created2020-12-04-
dc.date.issued2019-10-
dc.identifier.citationNATURE, v.574, no.7778, pp.365 - +-
dc.identifier.issn0028-0836-
dc.identifier.urihttp://hdl.handle.net/10203/278044-
dc.description.abstractDefinitive haematopoiesis in the fetal liver supports self-renewal and differentiation of haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly defined in humans. Here, using single-cell transcriptome profiling of approximately 140,000 liver and 74,000 skin, kidney and yolk sac cells, we identify the repertoire of human blood and immune cells during development. We infer differentiation trajectories from HSC/MPPs and evaluate the influence of the tissue microenvironment on blood and immune cell development. We reveal physiological erythropoiesis in fetal skin and the presence of mast cells, natural killer and innate lymphoid cell precursors in the yolk sac. We demonstrate a shift in the haemopoietic composition of fetal liver during gestation away from being predominantly erythroid, accompanied by a parallel change in differentiation potential of HSC/MPPs, which we functionally validate. Our integrated map of fetal liver haematopoiesis provides a blueprint for the study of paediatric blood and immune disorders, and a reference for harnessing the therapeutic potential of HSC/MPPs.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleDecoding human fetal liver haematopoiesis-
dc.typeArticle-
dc.identifier.wosid000490988300057-
dc.identifier.scopusid2-s2.0-85073611711-
dc.type.rimsART-
dc.citation.volume574-
dc.citation.issue7778-
dc.citation.beginningpage365-
dc.citation.endingpage+-
dc.citation.publicationnameNATURE-
dc.identifier.doi10.1038/s41586-019-1652-y-
dc.contributor.localauthorPark, Jong-Eun-
dc.contributor.nonIdAuthorPopescu, Dorin-Mirel-
dc.contributor.nonIdAuthorBotting, Rachel A.-
dc.contributor.nonIdAuthorStephenson, Emily-
dc.contributor.nonIdAuthorGreen, Kile-
dc.contributor.nonIdAuthorWebb, Simone-
dc.contributor.nonIdAuthorJardine, Laura-
dc.contributor.nonIdAuthorCalderbank, Emily F.-
dc.contributor.nonIdAuthorPolanski, Krzysztof-
dc.contributor.nonIdAuthorGoh, Issac-
dc.contributor.nonIdAuthorEfremova, Mirjana-
dc.contributor.nonIdAuthorAcres, Meghan-
dc.contributor.nonIdAuthorMaunder, Daniel-
dc.contributor.nonIdAuthorVegh, Peter-
dc.contributor.nonIdAuthorGitton, Yorick-
dc.contributor.nonIdAuthorVento-Tormo, Roser-
dc.contributor.nonIdAuthorMiao, Zhichao-
dc.contributor.nonIdAuthorDixon, David-
dc.contributor.nonIdAuthorRowell, Rachel-
dc.contributor.nonIdAuthorMcDonald, David-
dc.contributor.nonIdAuthorFletcher, James-
dc.contributor.nonIdAuthorPoyner, Elizabeth-
dc.contributor.nonIdAuthorReynolds, Gary-
dc.contributor.nonIdAuthorMather, Michael-
dc.contributor.nonIdAuthorMoldovan, Corina-
dc.contributor.nonIdAuthorMamanova, Lira-
dc.contributor.nonIdAuthorGreig, Frankie-
dc.contributor.nonIdAuthorYoung, Matthew D.-
dc.contributor.nonIdAuthorMeyer, Kerstin B.-
dc.contributor.nonIdAuthorLisgo, Steven-
dc.contributor.nonIdAuthorBacardit, Jaume-
dc.contributor.nonIdAuthorFuller, Andrew-
dc.contributor.nonIdAuthorMillar, Ben-
dc.contributor.nonIdAuthorInnes, Barbara-
dc.contributor.nonIdAuthorLindsay, Susan-
dc.contributor.nonIdAuthorStubbington, Michael J. T.-
dc.contributor.nonIdAuthorKowalczyk, Monika S.-
dc.contributor.nonIdAuthorLi, Bo-
dc.contributor.nonIdAuthorAshenberg, Orr-
dc.contributor.nonIdAuthorTabaka, Marcin-
dc.contributor.nonIdAuthorDionne, Danielle-
dc.contributor.nonIdAuthorTickle, Timothy L.-
dc.contributor.nonIdAuthorSlyper, Michal-
dc.contributor.nonIdAuthorRozenblatt-Rosen, Orit-
dc.contributor.nonIdAuthorFilby, Andrew-
dc.contributor.nonIdAuthorCarey, Peter-
dc.contributor.nonIdAuthorVillani, Alexandra-Chloe-
dc.contributor.nonIdAuthorRoy, Anindita-
dc.contributor.nonIdAuthorRegev, Aviv-
dc.contributor.nonIdAuthorChedotal, Alain-
dc.contributor.nonIdAuthorRoberts, Irene-
dc.contributor.nonIdAuthorGottgens, Berthold-
dc.contributor.nonIdAuthorBehjati, Sam-
dc.contributor.nonIdAuthorLaurenti, Elisa-
dc.contributor.nonIdAuthorTeichmann, Sarah A.-
dc.contributor.nonIdAuthorHaniffa, Muzlifah-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusCELL DEVELOPMENT-
dc.subject.keywordPlusSTEM-CELLS-
dc.subject.keywordPlusPROGENITORS-
dc.subject.keywordPlusPOPULATION-
dc.subject.keywordPlusONTOGENY-
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