DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Jong-Eun | ko |
dc.contributor.author | Botting, Rachel A. | ko |
dc.contributor.author | Conde, Cecilia Dominguez | ko |
dc.contributor.author | Popescu, Dorin-Mirel | ko |
dc.contributor.author | Lavaert, Marieke | ko |
dc.contributor.author | Kunz, Daniel J. | ko |
dc.contributor.author | Goh, Issac | ko |
dc.contributor.author | Stephenson, Emily | ko |
dc.contributor.author | Ragazzini, Roberta | ko |
dc.contributor.author | Tuck, Elizabeth | ko |
dc.contributor.author | Wilbrey-Clark, Anna | ko |
dc.contributor.author | Roberts, Kenny | ko |
dc.contributor.author | Kedlian, Veronika R. | ko |
dc.contributor.author | Ferdinand, John R. | ko |
dc.contributor.author | He, Xiaoling | ko |
dc.contributor.author | Webb, Simone | ko |
dc.contributor.author | Maunder, Daniel | ko |
dc.contributor.author | Vandamme, Niels | ko |
dc.contributor.author | Mahbubani, Krishnaa T. | ko |
dc.contributor.author | Polanski, Krzysztof | ko |
dc.contributor.author | Mamanova, Lira | ko |
dc.contributor.author | Bolt, Liam | ko |
dc.contributor.author | Crossland, David | ko |
dc.contributor.author | de Rita, Fabrizio | ko |
dc.contributor.author | Fuller, Andrew | ko |
dc.contributor.author | Filby, Andrew | ko |
dc.contributor.author | Reynolds, Gary | ko |
dc.contributor.author | Dixon, David | ko |
dc.contributor.author | Saeb-Parsy, Kourosh | ko |
dc.contributor.author | Lisgo, Steven | ko |
dc.contributor.author | Henderson, Deborah | ko |
dc.contributor.author | Vento-Tormo, Roser | ko |
dc.contributor.author | Bayraktar, Omer A. | ko |
dc.contributor.author | Barker, Roger A. | ko |
dc.contributor.author | Meyer, Kerstin B. | ko |
dc.contributor.author | Saeys, Yvan | ko |
dc.contributor.author | Bonfanti, Paola | ko |
dc.contributor.author | Behjati, Sam | ko |
dc.contributor.author | Clatworthy, Menna R. | ko |
dc.contributor.author | Taghon, Tom | ko |
dc.contributor.author | Haniffa, Muzlifah | ko |
dc.contributor.author | Teichmann, Sarah A. | ko |
dc.date.accessioned | 2020-12-04T01:50:06Z | - |
dc.date.available | 2020-12-04T01:50:06Z | - |
dc.date.created | 2020-12-04 | - |
dc.date.created | 2020-12-04 | - |
dc.date.issued | 2020-02 | - |
dc.identifier.citation | SCIENCE, v.367, no.6480, pp.868 - + | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | http://hdl.handle.net/10203/278037 | - |
dc.description.abstract | The thymus provides a nurturing environment for the differentiation and selection of T cells, a process orchestrated by their interaction with multiple thymic cell types. We used single-cell RNA sequencing to create a cell census of the human thymus across the life span and to reconstruct T cell differentiation trajectories and T cell receptor (TCR) recombination kinetics. Using this approach, we identified and located in situ CD8 alpha alpha(+) T cell populations, thymic fibroblast subtypes, and activated dendritic cell states. In addition, we reveal a bias in TCR recombination and selection, which is attributed to genomic position and the kinetics of lineage commitment. Taken together, our data provide a comprehensive atlas of the human thymus across the life span with new insights into human T cell development. | - |
dc.language | English | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | A cell atlas of human thymic development defines T cell repertoire formation | - |
dc.type | Article | - |
dc.identifier.wosid | 000530825200001 | - |
dc.identifier.scopusid | 2-s2.0-85079749861 | - |
dc.type.rims | ART | - |
dc.citation.volume | 367 | - |
dc.citation.issue | 6480 | - |
dc.citation.beginningpage | 868 | - |
dc.citation.endingpage | + | - |
dc.citation.publicationname | SCIENCE | - |
dc.identifier.doi | 10.1126/science.aay3224 | - |
dc.contributor.localauthor | Park, Jong-Eun | - |
dc.contributor.nonIdAuthor | Botting, Rachel A. | - |
dc.contributor.nonIdAuthor | Conde, Cecilia Dominguez | - |
dc.contributor.nonIdAuthor | Popescu, Dorin-Mirel | - |
dc.contributor.nonIdAuthor | Lavaert, Marieke | - |
dc.contributor.nonIdAuthor | Kunz, Daniel J. | - |
dc.contributor.nonIdAuthor | Goh, Issac | - |
dc.contributor.nonIdAuthor | Stephenson, Emily | - |
dc.contributor.nonIdAuthor | Ragazzini, Roberta | - |
dc.contributor.nonIdAuthor | Tuck, Elizabeth | - |
dc.contributor.nonIdAuthor | Wilbrey-Clark, Anna | - |
dc.contributor.nonIdAuthor | Roberts, Kenny | - |
dc.contributor.nonIdAuthor | Kedlian, Veronika R. | - |
dc.contributor.nonIdAuthor | Ferdinand, John R. | - |
dc.contributor.nonIdAuthor | He, Xiaoling | - |
dc.contributor.nonIdAuthor | Webb, Simone | - |
dc.contributor.nonIdAuthor | Maunder, Daniel | - |
dc.contributor.nonIdAuthor | Vandamme, Niels | - |
dc.contributor.nonIdAuthor | Mahbubani, Krishnaa T. | - |
dc.contributor.nonIdAuthor | Polanski, Krzysztof | - |
dc.contributor.nonIdAuthor | Mamanova, Lira | - |
dc.contributor.nonIdAuthor | Bolt, Liam | - |
dc.contributor.nonIdAuthor | Crossland, David | - |
dc.contributor.nonIdAuthor | de Rita, Fabrizio | - |
dc.contributor.nonIdAuthor | Fuller, Andrew | - |
dc.contributor.nonIdAuthor | Filby, Andrew | - |
dc.contributor.nonIdAuthor | Reynolds, Gary | - |
dc.contributor.nonIdAuthor | Dixon, David | - |
dc.contributor.nonIdAuthor | Saeb-Parsy, Kourosh | - |
dc.contributor.nonIdAuthor | Lisgo, Steven | - |
dc.contributor.nonIdAuthor | Henderson, Deborah | - |
dc.contributor.nonIdAuthor | Vento-Tormo, Roser | - |
dc.contributor.nonIdAuthor | Bayraktar, Omer A. | - |
dc.contributor.nonIdAuthor | Barker, Roger A. | - |
dc.contributor.nonIdAuthor | Meyer, Kerstin B. | - |
dc.contributor.nonIdAuthor | Saeys, Yvan | - |
dc.contributor.nonIdAuthor | Bonfanti, Paola | - |
dc.contributor.nonIdAuthor | Behjati, Sam | - |
dc.contributor.nonIdAuthor | Clatworthy, Menna R. | - |
dc.contributor.nonIdAuthor | Taghon, Tom | - |
dc.contributor.nonIdAuthor | Haniffa, Muzlifah | - |
dc.contributor.nonIdAuthor | Teichmann, Sarah A. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | ALPHA-BETA | - |
dc.subject.keywordPlus | ORGANOGENESIS | - |
dc.subject.keywordPlus | REARRANGEMENT | - |
dc.subject.keywordPlus | AVAILABILITY | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | SIGNALS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | FETAL | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.