Prenatal development of human immunity

Cited 52 time in webofscience Cited 42 time in scopus
  • Hit : 233
  • Download : 0
The blood and immune systems develop in parallel during early prenatal life. Waves of hematopoiesis separated in anatomical space and time give rise to circulating and tissue-resident immune cells. Previous observations have relied on animal models, which differ from humans in both their developmental timeline and exposure to microorganisms. Decoding the composition of the human immune system is now tractable using single-cell multi-omics approaches. Large-scale single-cell genomics, imaging technologies, and the Human Cell Atlas initiative have together enabled a systemslevel mapping of the developing human immune system and its emergent properties. Although the precise roles of specific immune cells during development require further investigation, the system as a whole displays malleable and responsive properties according to developmental need and environmental challenge.
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Issue Date
2020-05
Language
English
Article Type
Review
Citation

SCIENCE, v.368, no.6491, pp.600 - 603

ISSN
0036-8075
DOI
10.1126/science.aaz9330
URI
http://hdl.handle.net/10203/278031
Appears in Collection
MSE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 52 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0