DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lavaert, Marieke | ko |
dc.contributor.author | Liang, Kai Ling | ko |
dc.contributor.author | Vandamme, Niels | ko |
dc.contributor.author | Park, Jong-Eun | ko |
dc.contributor.author | Roels, Juliette | ko |
dc.contributor.author | Kowalczyk, Monica S. | ko |
dc.contributor.author | Li, Bo | ko |
dc.contributor.author | Ashenberg, Orr | ko |
dc.contributor.author | Tabaka, Marcin | ko |
dc.contributor.author | Dionne, Danielle | ko |
dc.contributor.author | Tickle, Timothy L. | ko |
dc.contributor.author | Slyper, Michal | ko |
dc.contributor.author | Rozenblatt-Rosen, Orit | ko |
dc.contributor.author | Vandekerckhove, Bart | ko |
dc.contributor.author | Leclercq, Georges | ko |
dc.contributor.author | Regev, Aviv | ko |
dc.contributor.author | Van Vlierberghe, Pieter | ko |
dc.contributor.author | Guilliams, Martin | ko |
dc.contributor.author | Teichmann, Sarah A. | ko |
dc.contributor.author | Saeys, Yvan | ko |
dc.contributor.author | Taghon, Tom | ko |
dc.date.accessioned | 2020-12-04T01:10:05Z | - |
dc.date.available | 2020-12-04T01:10:05Z | - |
dc.date.created | 2020-12-04 | - |
dc.date.created | 2020-12-04 | - |
dc.date.issued | 2020-06 | - |
dc.identifier.citation | IMMUNITY, v.52, no.6, pp.1088 - + | - |
dc.identifier.issn | 1074-7613 | - |
dc.identifier.uri | http://hdl.handle.net/10203/278030 | - |
dc.description.abstract | During postnatal life, thymopoiesis depends on the continuous colonization of the thymus by bone-marrow-derived hematopoietic progenitors that migrate through the bloodstream. The current understanding of the nature of thymic immigrants is largely based on datafrom pre-clinical models. Here, we employed single-cell RNA sequencing (scRNA-seq) to examine the immature postnatal thymocyte population in humans. Integration of bone marrow and peripheral blood precursor datasets identified two putative thymus seeding progenitors that varied in expression of CD7; CD10; and the homing receptors CCR7, CCR9, and ITGB7. Whereas both precursors supported T cell development, only one contributed to intrathymic dendritic cell (DC) differentiation, predominantly of plasmacytoid dendritic cells. Trajectory inference delineated the transcriptional dynamics underlying early human T lineage development, enabling prediction of transcription factor (TF) modules that drive stage-specific steps of human T cell development. This comprehensive dataset defines the expression signature of immature human thymocytes and provides a resource for the further study of human thymopoiesis. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | Integrated scRNA-Seq Identifies Human Postnatal Thymus Seeding Progenitors and Regulatory Dynamics of Differentiating Immature Thymocytes | - |
dc.type | Article | - |
dc.identifier.wosid | 000541890000020 | - |
dc.identifier.scopusid | 2-s2.0-85086606635 | - |
dc.type.rims | ART | - |
dc.citation.volume | 52 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 1088 | - |
dc.citation.endingpage | + | - |
dc.citation.publicationname | IMMUNITY | - |
dc.identifier.doi | 10.1016/j.immuni.2020.03.019 | - |
dc.contributor.localauthor | Park, Jong-Eun | - |
dc.contributor.nonIdAuthor | Lavaert, Marieke | - |
dc.contributor.nonIdAuthor | Liang, Kai Ling | - |
dc.contributor.nonIdAuthor | Vandamme, Niels | - |
dc.contributor.nonIdAuthor | Roels, Juliette | - |
dc.contributor.nonIdAuthor | Kowalczyk, Monica S. | - |
dc.contributor.nonIdAuthor | Li, Bo | - |
dc.contributor.nonIdAuthor | Ashenberg, Orr | - |
dc.contributor.nonIdAuthor | Tabaka, Marcin | - |
dc.contributor.nonIdAuthor | Dionne, Danielle | - |
dc.contributor.nonIdAuthor | Tickle, Timothy L. | - |
dc.contributor.nonIdAuthor | Slyper, Michal | - |
dc.contributor.nonIdAuthor | Rozenblatt-Rosen, Orit | - |
dc.contributor.nonIdAuthor | Vandekerckhove, Bart | - |
dc.contributor.nonIdAuthor | Leclercq, Georges | - |
dc.contributor.nonIdAuthor | Regev, Aviv | - |
dc.contributor.nonIdAuthor | Van Vlierberghe, Pieter | - |
dc.contributor.nonIdAuthor | Guilliams, Martin | - |
dc.contributor.nonIdAuthor | Teichmann, Sarah A. | - |
dc.contributor.nonIdAuthor | Saeys, Yvan | - |
dc.contributor.nonIdAuthor | Taghon, Tom | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | KILLER-CELL DEVELOPMENT | - |
dc.subject.keywordPlus | T-CELL | - |
dc.subject.keywordPlus | NATURAL-KILLER | - |
dc.subject.keywordPlus | LINEAGE COMMITMENT | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | HEMATOPOIETIC PROGENITORS | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | B-CELLS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INNATE | - |
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