Escherichia coli is engineered to grow on CO2 and formic acid

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We engineered Escherichia coli to grow on CO2 and formic acid alone by introducing the synthetic CO2 and formic acid assimilation pathway, expressing two formate dehydrogenase genes, fine-tuning metabolic fluxes and optimizing the levels of cytochrome bo3 and bd-I ubiquinol oxidase. Our engineered strain can grow to an optical density at 600 nm of 7.38 in 450 h, and shows promise as a platform strain growing on CO2 and formic acid alone.
Publisher
NATURE RESEARCH
Issue Date
2020-12
Language
English
Article Type
Article
Citation

NATURE MICROBIOLOGY, v.5, no.12, pp.1459 - 1463

ISSN
2058-5276
DOI
10.1038/s41564-020-00793-9
URI
http://hdl.handle.net/10203/277841
Appears in Collection
CBE-Journal Papers(저널논문)
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