DC Field | Value | Language |
---|---|---|
dc.contributor.author | Adam, Rene C. | ko |
dc.contributor.author | Yang, Hanseul | ko |
dc.contributor.author | Rockowitz, Shira | ko |
dc.contributor.author | Larsen, Samantha B. | ko |
dc.contributor.author | Nikolova, Maria | ko |
dc.contributor.author | Oristian, Daniel S. | ko |
dc.contributor.author | Polak, Lisa | ko |
dc.contributor.author | Kadaja, Meelis | ko |
dc.contributor.author | Asare, Amma | ko |
dc.contributor.author | Zheng, Deyou | ko |
dc.contributor.author | Fuchs, Elaine | ko |
dc.date.accessioned | 2020-11-17T02:55:15Z | - |
dc.date.available | 2020-11-17T02:55:15Z | - |
dc.date.created | 2020-11-17 | - |
dc.date.created | 2020-11-17 | - |
dc.date.issued | 2015-05 | - |
dc.identifier.citation | NATURE, v.521, no.7552, pp.366 - + | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | http://hdl.handle.net/10203/277329 | - |
dc.description.abstract | Adult stem cells occur in niches that balance self-renewal with lineage selection and progression during tissue homeostasis. Following injury, culture or transplantation, stem cells outside their niche often display fate flexibility(1-4). Here we show that super-enhancers(5) underlie the identity, lineage commitment and plasticity of adult stem cells in vivo. Using hair follicle as a model, we map the global chromatin domains of hair follicle stem cells and their committed progenitors in their native microenvironments. We show that super-enhancers and their dense clusters ('epicentres') of transcription factor binding sites undergo remodelling upon lineage progression. New fate is acquired by decommissioning old and establishing new super-enhancers and/or epicentres, an auto-regulatory process that abates one master regulator subset while enhancing another. We further show that when outside their niche, either in vitro or in wound-repair, hair follicle stem cells dynamically remodel super-enhancers in response to changes in their microenvironment. Intriguingly, some key super-enhancers shift epicentres, enabling their genes to remain active and maintain a transitional state in an ever-changing transcriptional landscape. Finally, we identify SOX9 as a crucial chromatin rheostat of hair follicle stem cell super-enhancers, and provide functional evidence that super-enhancers are dynamic, dense transcription-factor-binding platforms which are acutely sensitive to pioneer master regulators whose levels define not only spatial and temporal features of lineage-status but also stemness, plasticity in transitional states and differentiation. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice | - |
dc.type | Article | - |
dc.identifier.wosid | 000354816500059 | - |
dc.identifier.scopusid | 2-s2.0-84929211885 | - |
dc.type.rims | ART | - |
dc.citation.volume | 521 | - |
dc.citation.issue | 7552 | - |
dc.citation.beginningpage | 366 | - |
dc.citation.endingpage | + | - |
dc.citation.publicationname | NATURE | - |
dc.identifier.doi | 10.1038/nature14289 | - |
dc.contributor.localauthor | Yang, Hanseul | - |
dc.contributor.nonIdAuthor | Adam, Rene C. | - |
dc.contributor.nonIdAuthor | Rockowitz, Shira | - |
dc.contributor.nonIdAuthor | Larsen, Samantha B. | - |
dc.contributor.nonIdAuthor | Nikolova, Maria | - |
dc.contributor.nonIdAuthor | Oristian, Daniel S. | - |
dc.contributor.nonIdAuthor | Polak, Lisa | - |
dc.contributor.nonIdAuthor | Kadaja, Meelis | - |
dc.contributor.nonIdAuthor | Asare, Amma | - |
dc.contributor.nonIdAuthor | Zheng, Deyou | - |
dc.contributor.nonIdAuthor | Fuchs, Elaine | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | IDENTITY GENES | - |
dc.subject.keywordPlus | SELF-RENEWAL | - |
dc.subject.keywordPlus | NICHE | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | GENOME | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | INHIBITION | - |
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