DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Hanseul | ko |
dc.contributor.author | Schramek, Daniel | ko |
dc.contributor.author | Adam, Rene C. | ko |
dc.contributor.author | Keyes, Brice E. | ko |
dc.contributor.author | Wang, Ping | ko |
dc.contributor.author | Zheng, Deyou | ko |
dc.contributor.author | Fuchs, Elaine | ko |
dc.date.accessioned | 2020-11-17T01:55:22Z | - |
dc.date.available | 2020-11-17T01:55:22Z | - |
dc.date.created | 2020-11-17 | - |
dc.date.created | 2020-11-17 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.citation | ELIFE, v.4 | - |
dc.identifier.issn | 2050-084X | - |
dc.identifier.uri | http://hdl.handle.net/10203/277325 | - |
dc.description.abstract | Tumor-initiating stem cells (SCs) exhibit distinct patterns of transcription factors and gene expression compared to healthy counterparts. Here, we show that dramatic shifts in large open-chromatin domain (super-enhancer) landscapes underlie these differences and reflect tumor microenvironment. By in vivo super-enhancer and transcriptional profiling, we uncover a dynamic cancer-specific epigenetic network selectively enriched for binding motifs of a transcription factor cohort expressed in squamous cell carcinoma SCs (SCC-SCs). Many of their genes, including Ets2 and Elk3, are themselves regulated by SCC-SC super-enhancers suggesting a cooperative feed forward loop. Malignant progression requires these genes, whose knockdown severely impairs tumor growth and prohibits progression from benign papillomas to SCCs. ETS2-deficiency disrupts the SCC-SC super-enhancer landscape and downstream cancer genes while ETS2-overactivation in epidermal-SCs induces hyperproliferation and SCC super-enhancer-associated genes Fos, Junb and Klf5. Together, our findings unearth an essential regulatory network required for the SCC-SC chromatin landscape and unveil its importance in malignant progression. | - |
dc.language | English | - |
dc.publisher | ELIFE SCIENCES PUBLICATIONS LTD | - |
dc.title | ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas | - |
dc.type | Article | - |
dc.identifier.wosid | 000373883600001 | - |
dc.identifier.scopusid | 2-s2.0-84955279894 | - |
dc.type.rims | ART | - |
dc.citation.volume | 4 | - |
dc.citation.publicationname | ELIFE | - |
dc.identifier.doi | 10.7554/eLife.10870 | - |
dc.contributor.localauthor | Yang, Hanseul | - |
dc.contributor.nonIdAuthor | Schramek, Daniel | - |
dc.contributor.nonIdAuthor | Adam, Rene C. | - |
dc.contributor.nonIdAuthor | Keyes, Brice E. | - |
dc.contributor.nonIdAuthor | Wang, Ping | - |
dc.contributor.nonIdAuthor | Zheng, Deyou | - |
dc.contributor.nonIdAuthor | Fuchs, Elaine | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | NONMELANOMA SKIN-CANCER | - |
dc.subject.keywordPlus | STEM-CELL | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | SUPER-ENHANCERS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | NICHE | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | MACROPHAGE | - |
dc.subject.keywordPlus | EXPRESSION | - |
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