Role of VEGF/VEGFR and angiopoietin/tie system in blood and lymphatic vessels remodeling = 혈관 및 림프관의 리모델링 과정에서 VEGF/VEGFR 와 angiopoietin/tie 시스템의 역할

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In the multicellular organisms, highly-branched blood and lymphatic vascular networks are responsible for transporting gases, nutrients, signaling molecules and circulating cells between tissues and organs through the body. The vascular networks are formed by endothelial cells which are tightly regulated to maintain the homeostasis in the organism via various signaling pathways. Occasionally, dysfunction in the vascular networks is associated with many diseases such as cancer and cardiovascular diseases. In early embryonic development, endothelial cells aggregate to form primitive blood vessels (vasculogenesis). Once the blood circulation becomes established, initial vascular plexus develops into a complex and functional vascular structure through various vascular remodeling processes such as endothelial cell sprouting, pruning, and vascular branching (angiogenesis). Vascular endothelial growth factor (VEGF)/VEGF receptor and angiopoietin/Tie receptor system have been identified to be endothelial cell-specific and essential for the formation and maintenance of vascular network not merely in embryonic development but also in the adult life. Here, I divided this thesis into three chapters as follows: the development of lymphatic vessels in the mouse intestine (part I), role of VEGF-C,D/VEGFR-3 system in inflammation-induced lymphangiogenesis (part II), and role of angiopoietins/Tie2 system in angiogenesis and lymphangiogenesis (part III). $\Bf{Part I. Abstract}$ Lymphatic vessels in the small intestine serve as essential conduits for the absorption and transport of lipids from the intestine to the thoracic duct. Although the morphology and function of the intestinal lymphatic vasculature are well known, little is known about the embryonic development of these vessels. In this study, I examined development of lymphatic and blood vasculatures in the intestinal tube during mouse embryonic development by immunostaining with recently discovered molecular marker...
Advisors
Koh, Gou-Youngresearcher고규영researcher
Description
한국과학기술원 : 생명과학과,
Publisher
한국과학기술원
Issue Date
2010
Identifier
418749/325007  / 020047044
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 생명과학과, 2010.2, [ xiii, 115 p. ]

Keywords

VEGF; Vascular Remodeling; Lymphangiogenesis; Angiogenesis; Angiopoietin; 안지오포이에틴; 혈관내피성장인자; 혈관 리모델링; 림프관 신생; 혈관 신생

URI
http://hdl.handle.net/10203/27694
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=418749&flag=dissertation
Appears in Collection
BS-Theses_Ph.D.(박사논문)
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