An interactive retrieval system for clinical trial studies with context-dependent protocol elements

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A well-defined protocol for a clinical trial guarantees a successful outcome report. When designing the protocol, most researchers refer to electronic databases and extract protocol elements using a keyword search. However, state-of-the-art database systems only offer text-based searches for user-entered keywords. In this study, we present a database system with a context-dependent and protocol-element-selection function for successfully designing a clinical trial protocol. To do this, we first introduce a database for a protocol retrieval system constructed from individual protocol data extracted from 184,634 clinical trials and 13,210 frame structures of clinical trial protocols. The database contains a variety of semantic information that allows the filtering of protocols during the search operation. Based on the database, we developed a web application called the clinical trial protocol database system (CLIPS; available at https://corus.kaist.edu/clips). This system enables an interactive search by utilizing protocol elements. To enable an interactive search for combinations of protocol elements, CLIPS provides optional next element selection according to the previous element in the form of a connected tree. The validation results show that our method achieves better performance than that of existing databases in predicting phenotypic features.
Publisher
PUBLIC LIBRARY SCIENCE
Issue Date
2020-09
Language
English
Article Type
Article
Citation

PLOS ONE, v.15, no.9

ISSN
1932-6203
DOI
10.1371/journal.pone.0238290
URI
http://hdl.handle.net/10203/276921
Appears in Collection
BiS-Journal Papers(저널논문)
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