Astrocyte-Encapsulated Hydrogel Microfibers Enhance Neuronal Circuit Generation

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dc.contributor.authorKim, Beom Jinko
dc.contributor.authorChoi, Ji Yuko
dc.contributor.authorChoi, Hyunwooko
dc.contributor.authorHan, Solko
dc.contributor.authorSeo, Jeongyeonko
dc.contributor.authorKim, Jungnamko
dc.contributor.authorJoo, Sunghoonko
dc.contributor.authorKim, Hyo Minko
dc.contributor.authorOh, Chungikko
dc.contributor.authorHong, Seungbumko
dc.contributor.authorKim, Pilnamko
dc.contributor.authorChoi, Insung S.ko
dc.date.accessioned2020-10-21T07:55:46Z-
dc.date.available2020-10-21T07:55:46Z-
dc.date.created2020-02-04-
dc.date.issued2020-03-
dc.identifier.citationADVANCED HEALTHCARE MATERIALS, v.9, no.5, pp.1901072-
dc.identifier.issn2192-2640-
dc.identifier.urihttp://hdl.handle.net/10203/276824-
dc.description.abstractAstrocytes, the most representative glial cells in the brain, play a multitude of crucial functions for proper neuronal development and synaptic-network formation, including neuroprotection as well as physical and chemical support. However, little attention has been paid, in the neuroregenerative medicine and related fields, to the cytoprotective incorporation of astrocytes into neuron-culture scaffolds and full-fledged functional utilization of encapsulated astrocytes for controlled neuronal development. In this article, a 3D neurosupportive culture system for enhanced induction of neuronal circuit generation is reported, where astrocytes are confined in hydrogel microfibers and protected from the outside. The astrocyte-encapsulated microfibers significantly accelerate the neurite outgrowth and guide its directionality, and enhance the synaptic formation, without any physical contact with the neurons. This astrocyte-laden system provides a pivotal culture scaffold for advanced development of cell-based therapeutics for neural injuries, such as spinal cord injury.-
dc.languageEnglish-
dc.publisherWILEY-
dc.titleAstrocyte-Encapsulated Hydrogel Microfibers Enhance Neuronal Circuit Generation-
dc.typeArticle-
dc.identifier.wosid000507954200001-
dc.identifier.scopusid2-s2.0-85078775221-
dc.type.rimsART-
dc.citation.volume9-
dc.citation.issue5-
dc.citation.beginningpage1901072-
dc.citation.publicationnameADVANCED HEALTHCARE MATERIALS-
dc.identifier.doi10.1002/adhm.201901072-
dc.contributor.localauthorHong, Seungbum-
dc.contributor.localauthorKim, Pilnam-
dc.contributor.localauthorChoi, Insung S.-
dc.contributor.nonIdAuthorChoi, Hyunwoo-
dc.contributor.nonIdAuthorJoo, Sunghoon-
dc.contributor.nonIdAuthorOh, Chungik-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorastrocytes-
dc.subject.keywordAuthorcell encapsulation-
dc.subject.keywordAuthorneuron culture systems-
dc.subject.keywordAuthorprimary hippocampal neurons-
dc.subject.keywordPlusHIPPOCAMPAL-NEURONS-
dc.subject.keywordPlusNEURITE OUTGROWTH-
dc.subject.keywordPlusSYNAPSE FORMATION-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusNETWORKS-
dc.subject.keywordPlusSYSTEM-
dc.subject.keywordPlusBRAIN-
dc.subject.keywordPlusFABRICATION-
dc.subject.keywordPlusCOCULTURE-
dc.subject.keywordPlusSCAFFOLDS-
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MS-Journal Papers(저널논문)BiS-Journal Papers(저널논문)CH-Journal Papers(저널논문)
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