Astrocyte-Encapsulated Hydrogel Microfibers Enhance Neuronal Circuit Generation

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Astrocytes, the most representative glial cells in the brain, play a multitude of crucial functions for proper neuronal development and synaptic-network formation, including neuroprotection as well as physical and chemical support. However, little attention has been paid, in the neuroregenerative medicine and related fields, to the cytoprotective incorporation of astrocytes into neuron-culture scaffolds and full-fledged functional utilization of encapsulated astrocytes for controlled neuronal development. In this article, a 3D neurosupportive culture system for enhanced induction of neuronal circuit generation is reported, where astrocytes are confined in hydrogel microfibers and protected from the outside. The astrocyte-encapsulated microfibers significantly accelerate the neurite outgrowth and guide its directionality, and enhance the synaptic formation, without any physical contact with the neurons. This astrocyte-laden system provides a pivotal culture scaffold for advanced development of cell-based therapeutics for neural injuries, such as spinal cord injury.
Publisher
WILEY
Issue Date
2020-03
Language
English
Article Type
Article
Citation

ADVANCED HEALTHCARE MATERIALS, v.9, no.5, pp.1901072

ISSN
2192-2640
DOI
10.1002/adhm.201901072
URI
http://hdl.handle.net/10203/276824
Appears in Collection
MS-Journal Papers(저널논문)BiS-Journal Papers(저널논문)CH-Journal Papers(저널논문)
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