Study of the correlation between phosphatase regenerating liver 1 (PRL-1) and p53, functional characterization of PRL-1 using drosophila model = Regenerating liver 1 phosphatase (PRL-1)와 p53의 상호관련성 및 초파리 동물모델을 이용한 PRL-1의 기능 연구

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Part 1 The reversible protein phosphorylation by kanases and phosphatases in signal transduction pathways regulates biological functions involved in cellular processes. One of phosphatases, protein tyrosine phosphatase (PTP) catalyzes the hydrolysis of the phosphate monoesters specifically on tyrosine residues and members of the PTP family regulate a variety of cellular processes including cell growth, differentiation, mitotic cell cycle, and oncogenic transformation. Several protein tyrosine phosphatases (PTPs) have been implicated in various diseases and have emerged as one of therapeutic targets. One of protein tyrosine phosphatases (PTPs), phosphatase of regenerating liver (PRL) family has been known to be associated with tumorigenesis and cancer metastasis. However, intracellular signal and biological function of phosphatase of regenerating liver (PRL) family are not clearly elucidated. Recently, it has been reported that phosphatase of regenerating liver (PRL)-1 and phosphatase of regenerating liver (PRL)-2 are involved in the enhanced cell cycle through a decrease in protein level of p21, one of p53 targets, and phosphatase of regenerating liver (PRL)-3 activate PI3K/Akt signaling during promoting the epithelial-mesenchymal transition (EMT). The effects of phosphatases of regenerating liver (PRLs) on p21 expression and PI3K/Akt activation suggest that phosphatases of regenerating liver (PRLs) may be correlated with the levels of the p53 protein regulating p21 expression and related with AKT signaling-mediated mouse double minute 2 (MDM2) phosphorylation. Therefore, I investigated the potential relationship between phosphatase of regenerating liver (PRL)-1 and p53. Most of the p53 target genes, all except mouse double minute 2 (MDM2), constitutively photomorphogenic 1 (COP1), and p53 induced protein with a RING-H2 domain (PIRH2), take functions in apoptosis, senescence, differentiation, anti-angiogenesis, and cell cycle arrest. The previously mentioned ...
Yoo, Ook-Joonresearcher유욱준researcher
한국과학기술원 : 의과학학제전공,
Issue Date
327760/325007  / 020075061

학위논문(박사) - 한국과학기술원 : 의과학학제전공, 2009. 8., [ ix, 74, iv, 33 p. ]


PRL-1; p53; PI3K; PTP4A1; p53 target; p53 타겟유전자; 탈인산화효소; 발암유전자; 전이암; PRL-1; PRL-1; p53; PI3K; PTP4A1; p53 target; p53 타겟유전자; 탈인산화효소; 발암유전자; 전이암; PRL-1

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