DC Field | Value | Language |
---|---|---|
dc.contributor.author | Son, Seung-Myoung | ko |
dc.contributor.author | Woo, Chang Gok | ko |
dc.contributor.author | Kim, Dae Hoon | ko |
dc.contributor.author | Yun, Hyo Yung | ko |
dc.contributor.author | Kim, Hongsik | ko |
dc.contributor.author | Kim, Hee Kyung | ko |
dc.contributor.author | Yang, Yaewon | ko |
dc.contributor.author | Kwon, Jihyun | ko |
dc.contributor.author | Kwon, Minsuk | ko |
dc.contributor.author | Kim, Tae-Yong | ko |
dc.contributor.author | Kim, Hyung-Don | ko |
dc.contributor.author | Koh, June-Young | ko |
dc.contributor.author | Park, Su-Hyung | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Han, Hye Sook | ko |
dc.date.accessioned | 2020-10-21T02:55:07Z | - |
dc.date.available | 2020-10-21T02:55:07Z | - |
dc.date.created | 2020-10-05 | - |
dc.date.issued | 2020-08 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v.10, no.1, pp.14293 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/10203/276767 | - |
dc.description.abstract | This study compared the tumor immune microenvironments (TIMEs) of primary gastric cancer (PGC) and paired metastatic gastric cancer (MGC). CD4(+) and CD8(+) T-cell density and PD-L1 expression were evaluated by multiplex immunohistochemistry, DNA mismatch repair (MMR) by immunohistochemistry, and immune-related genes by RNA sequencing. Twenty-three patients who underwent surgical treatment for PGC and MGC were enrolled in this study. CD8(+) T-cell, PD-L1(+) cell, and PD-L1(+)CK(+) cell densities were significantly lower in MGC than PGC. PD-L1 positivity using a combined positive score (>= 1%) and deficient MMR were observed in 52.2% and 8.7% of PGC samples, respectively, whereas both occurred in only 4.3% of MGC samples. The most frequent TIME types were inflamed (34.8%) and adaptive immune resistance (34.8%) in PGC, and immune desert (65.2%) and immunological ignorance (73.9%) in MGC. In transcriptome analysis, the expression of the T-cell inflamed gene set and co-stimulatory gene module was down-regulated in MGC compared to PGC. The total CD8(+) T-cell density was an independent prognostic marker in both PGC and MGC (univariate P=0.002, multivariate P=0.006). Our result suggest that the TIME of metastatic tumors was less immunologically active compared to that of primary tumors in gastric cancer patients. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Distinct tumor immune microenvironments in primary and metastatic lesions in gastric cancer patients | - |
dc.type | Article | - |
dc.identifier.wosid | 000570035500040 | - |
dc.identifier.scopusid | 2-s2.0-85089980615 | - |
dc.type.rims | ART | - |
dc.citation.volume | 10 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 14293 | - |
dc.citation.publicationname | SCIENTIFIC REPORTS | - |
dc.identifier.doi | 10.1038/s41598-020-71340-z | - |
dc.contributor.localauthor | Park, Su-Hyung | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Son, Seung-Myoung | - |
dc.contributor.nonIdAuthor | Woo, Chang Gok | - |
dc.contributor.nonIdAuthor | Kim, Dae Hoon | - |
dc.contributor.nonIdAuthor | Yun, Hyo Yung | - |
dc.contributor.nonIdAuthor | Kim, Hongsik | - |
dc.contributor.nonIdAuthor | Kim, Hee Kyung | - |
dc.contributor.nonIdAuthor | Yang, Yaewon | - |
dc.contributor.nonIdAuthor | Kwon, Jihyun | - |
dc.contributor.nonIdAuthor | Kwon, Minsuk | - |
dc.contributor.nonIdAuthor | Kim, Tae-Yong | - |
dc.contributor.nonIdAuthor | Kim, Hyung-Don | - |
dc.contributor.nonIdAuthor | Han, Hye Sook | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | INFILTRATING LYMPHOCYTES | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordPlus | NIVOLUMAB | - |
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