DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Llim, Dae-Sik | - |
dc.contributor.advisor | 임대식 | - |
dc.contributor.author | Lee, Joo-Hyeon | - |
dc.contributor.author | 이주현 | - |
dc.date.accessioned | 2011-12-12T07:55:40Z | - |
dc.date.available | 2011-12-12T07:55:40Z | - |
dc.date.issued | 2008 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=310402&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/27670 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 생명과학과, 2008.2, [ vii, 97 p. ] | - |
dc.description.abstract | The role and molecular mechanisms of a new Hippo signaling pathway are not fully understood in mammals. Here, we generated mice lacking WW45 and reveal a crucial role of WW45 in cell-cycle exit for epithelial terminal differentiation. Many organs in mutant embryos displayed hyperplasia accompanied by defects of terminal differentiation of epithelial cells owing to impairment of proliferation stop of epithelial cells rather than intrinsic acceleration of proliferation during differentiation. Importantly, MST1 signaling pathway is specifically activated in only differentiating epithelial cells. We also found that WW45 is required for MST1 activation and translocation to the nucleus for subsequent LATS1/2 activation, which then phosphorylate serine 127 of YAP upon differentiation signal. This phosphorylated YAP translocates from the nucleus into the cytoplasm, thereby resulting in cell-cycle exit and terminal differentiation. Collectively, these data provide compelling evidence that WW45 is a key mediator of MST1 signaling in the coordinate coupling of proliferation stop with terminal differentiation for proper epithelial tissue development in mammals. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | cell cycle exit | - |
dc.subject | epithelial differentiation | - |
dc.subject | hyperplasia | - |
dc.subject | knockout mouse | - |
dc.subject | tumorigenesis | - |
dc.subject | 세포주기 | - |
dc.subject | 상피 분화 | - |
dc.subject | 과증식 | - |
dc.subject | 유전자 적중 마우스 | - |
dc.subject | 종양 | - |
dc.subject | cell cycle exit | - |
dc.subject | epithelial differentiation | - |
dc.subject | hyperplasia | - |
dc.subject | knockout mouse | - |
dc.subject | tumorigenesis | - |
dc.subject | 세포주기 | - |
dc.subject | 상피 분화 | - |
dc.subject | 과증식 | - |
dc.subject | 유전자 적중 마우스 | - |
dc.subject | 종양 | - |
dc.title | (A) crucial role of WW45 in developing epithelial tissues in the mouse | - |
dc.title.alternative | WW45 유전자의 마우스 상피조직에서의 세포주기 및 분화 조절 기능에 관한 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 310402/325007 | - |
dc.description.department | 한국과학기술원 : 생명과학과, | - |
dc.identifier.uid | 020035239 | - |
dc.contributor.localauthor | Llim, Dae-Sik | - |
dc.contributor.localauthor | 임대식 | - |
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