Transient effect of mossy fiber stimulation on spatial firing of CA3 neurons in familiar and novel environments

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Hippocampal mossy fibers have long been proposed to impose new patterns to learn onto CA3 neurons during new memory formation. However, inconsistent with this theory, we found in our previous study that mossy fiber stimulation induces only transient changes in CA3 spatial firing in a familiar environment. Here, we tested whether mossy fiber stimulation affects CA3 spatial firing differently between familiar and novel environments. We compared spatial firing of CA3 neurons before and after optogenetic stimulation of mossy fibers in freely behaving mice in a familiar and three sets of novel environments. We found that CA3 neurons are more responsive to mossy fiber stimulation in the novel than familiar environments. However, we failed to obtain evidence for long-lasting effect of mossy fiber stimulation on spatial firing of CA3 neurons in both the familiar and novel environments. Our results provide further evidence against the view that mossy fibers carry teaching signals.
Publisher
WILEY
Issue Date
2020-07
Language
English
Article Type
Article
Citation

HIPPOCAMPUS, v.30, no.7, pp.693 - 702

ISSN
1050-9631
DOI
10.1002/hipo.23190
URI
http://hdl.handle.net/10203/276654
Appears in Collection
BS-Journal Papers(저널논문)
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