A neural basis for tonic suppression of sodium appetite

Cited 2 time in webofscience Cited 0 time in scopus
  • Hit : 49
  • Download : 0
DC FieldValueLanguage
dc.contributor.authorPark, Seahyungko
dc.contributor.authorWilliams, Kevin W.ko
dc.contributor.authorLiu, Chenko
dc.contributor.authorSohn, Jong-Wooko
dc.date.accessioned2020-10-05T02:55:05Z-
dc.date.available2020-10-05T02:55:05Z-
dc.date.created2020-02-01-
dc.date.issued2020-03-
dc.identifier.citationNATURE NEUROSCIENCE, v.23, no.3, pp.423 - +-
dc.identifier.issn1097-6256-
dc.identifier.urihttp://hdl.handle.net/10203/276461-
dc.description.abstractSodium appetite is a powerful form of motivation that can drive ingestion of high, yet aversive concentrations of sodium in animals that are depleted of sodium. However, in normal conditions, sodium appetite is suppressed to prevent homeostatic deviations. Although molecular and neural mechanisms underlying the stimulation of sodium appetite have received much attention recently, mechanisms that inhibit sodium appetite remain largely obscure. Here we report that serotonin 2c receptor (Htr2c)-expressing neurons in the lateral parabrachial nucleus (LPBNHtr2c neurons) inhibit sodium appetite. Activity of these neurons is regulated by bodily sodium content, and their activation can rapidly suppress sodium intake. Conversely, inhibition of these neurons specifically drives sodium appetite, even during euvolemic conditions. Notably, the physiological role of Htr2c expressed by LPBN neurons is to disinhibit sodium appetite. Our results suggest that LPBNHtr2c neurons act as a brake against sodium appetite and that their alleviation is required for the full manifestation of sodium appetite. High concentrations of sodium are normally unpalatable. This study shows a neural population in the brainstem that suppresses appetite for sodium. Reducing the activity of these neurons can drive ingestion of high concentrations of sodium.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleA neural basis for tonic suppression of sodium appetite-
dc.typeArticle-
dc.identifier.wosid000508325100003-
dc.identifier.scopusid2-s2.0-85078230272-
dc.type.rimsART-
dc.citation.volume23-
dc.citation.issue3-
dc.citation.beginningpage423-
dc.citation.endingpage+-
dc.citation.publicationnameNATURE NEUROSCIENCE-
dc.identifier.doi10.1038/s41593-019-0573-2-
dc.contributor.localauthorSohn, Jong-Woo-
dc.contributor.nonIdAuthorWilliams, Kevin W.-
dc.contributor.nonIdAuthorLiu, Chen-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusLATERAL PARABRACHIAL NUCLEUS-
dc.subject.keywordPlusSALT APPETITE-
dc.subject.keywordPlusSTRIA TERMINALIS-
dc.subject.keywordPlusCGRP NEURONS-
dc.subject.keywordPlusHSD2 NEURONS-
dc.subject.keywordPlusBED NUCLEI-
dc.subject.keywordPlusRECEPTOR-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusTASTE-
dc.subject.keywordPlusPROJECTIONS-
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 2 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0