DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Joe, Cheol-O. | - |
dc.contributor.advisor | 조철오 | - |
dc.contributor.author | Tak, Hee-jae | - |
dc.contributor.author | 탁희재 | - |
dc.date.accessioned | 2011-12-12T07:55:14Z | - |
dc.date.available | 2011-12-12T07:55:14Z | - |
dc.date.issued | 2008 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=295336&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/27641 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 생명과학과, 2008.2, [ viii, 94 p. ] | - |
dc.description.abstract | The signal pathway by which 14-3-3ε inhibits cell migration induced by MAPK-activated protein kinase 5 (MK5) was investigated in cultured HeLa cells. Both $in vivo$ and $in vitro$ analyses have revealed that 14-3-3ε interacts with MK5. Other MKs including MK2 and MK3 appeared to fail to interact with 14-3-3ε. 14-3-3ε bound to MK5 inhibits the phosphorylation of HSP27, a known substrate of MK5. Disturbance of actin cytoskeleton organization by 14-3-3ε was shown in transfected cells transiently expressing 14-3-3ε as well as established cells stably expressing 14-3-3ε. Moreover, overexpression of 14-3-3ε resulted in the inhibition of cell migration induced by MK5 overexpression or TNFα treatment. Results in this study suggest that 14-3-3ε bound to MK5 inhibits cell migration by inhibiting the phosphorylation of HSP27 whose phosphorylation regulates F-actin polymerization, actin cytoskeleton organization and subsequent actinfilament dynamics. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | MK5 | - |
dc.subject | 14-3-3ε | - |
dc.subject | HSP27 | - |
dc.subject | cell migration | - |
dc.subject | F-actin polymerization | - |
dc.subject | MK5 | - |
dc.subject | 14-3-3ε | - |
dc.subject | HSP27 | - |
dc.subject | 세포이동 | - |
dc.subject | F-액틴 중합반응 | - |
dc.subject | MK5 | - |
dc.subject | 14-3-3ε | - |
dc.subject | HSP27 | - |
dc.subject | cell migration | - |
dc.subject | F-actin polymerization | - |
dc.subject | MK5 | - |
dc.subject | 14-3-3ε | - |
dc.subject | HSP27 | - |
dc.subject | 세포이동 | - |
dc.subject | F-액틴 중합반응 | - |
dc.title | Inhibition of MK5-mediated cell migration by $14-3-3\epsilon$ | - |
dc.title.alternative | MK5에 의한 세포 이동에 미치는 14-3-3ε의 영향 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 295336/325007 | - |
dc.description.department | 한국과학기술원 : 생명과학과, | - |
dc.identifier.uid | 020035890 | - |
dc.contributor.localauthor | Joe, Cheol-O. | - |
dc.contributor.localauthor | 조철오 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.