(The) different associations of PADI4 haplotypes and HLA-DRB1 shared epitope alleles with anti-cyclic citrullinated peptide antibody levels in rheumatoid arthritis. = PADI4 일배체형 및 HLA-DRB1 공유 항원기와 류마티스 관절염 환자의 고리형 시트룰린 펩타이드 항체 수준 사이의 연관성.

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Anti-cyclic citrullinated peptide antibodies (anti-CCPs) are rheumatoid arthritis (RA)-specific serologic markers. RA susceptibility has been associated with HLA-DRB1 shared epitope (SE) alleles and single-nucleotide polymorphism (SNP) haplotypes in the peptidylarginine deiminase 4 gene (PADI4). Here, we tested whether anti-CCP levels are associated with PADI4 haplotypes and/or SE alleles in Korean RA patients. Three nonsynonymous SNPs in PADI4 (padi4_89, padi4_90 and padi4_92) and SE alleles were genotyped, and serum anti-CCP levels were measured in 311 patients having non-erosive or erosive RA. The relationships between anti-CCP levels and PADI4 haplotypes and/or SE alleles were statistically examined. Anti-CCP levels were significantly higher in PADI4 RA-risk haplotype carriers versus non-carriers among anti-CCP-positive patients having non-erosive RA (P = 0.022, 2.0-fold in mean level) and among those afflicted with RA for 40 months or less (P = 0.019, 2.1-fold), but not among patients having erosive RA or afflicted longer. In contrast, the levels were significantly higher in SE carriers versus non-carriers among patients with erosive RA (P = 0.000098, 2.0-fold) and among those afflicted with RA for 122 months or more (P = 0.00059, 2.2-fold), but not among patients having non-erosive RA or afflicted shorter. Conclusively, the PADI4 RA-risk haplotype is associated with increased anti-CCP levels in non-erosive but not in erosive RA patients and PADI4 may play a role in early RA. In contrast, SE alleles are associated with increased anti-CCP levels in erosive but not in non-erosive RA patients and SE may play a role in very late RA.
Advisors
Kang, Chang-Wonresearcher강창원researcher
Description
한국과학기술원 : 생명과학과,
Publisher
한국과학기술원
Issue Date
2007
Identifier
263440/325007  / 020005316
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 생명과학과, 2007.2, [ viii, 89 p. ]

Keywords

anti-CCP; Rheumatoid arthritis; PADI4; 공유 항원기; 일배체형; 류마티스 관절염; SE

URI
http://hdl.handle.net/10203/27628
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=263440&flag=dissertation
Appears in Collection
BS-Theses_Ph.D.(박사논문)
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