Histamine and its receptors modulate temperature preference behavior in Drosophila = 히스타민 과 그 수용체가 초파리의 온도선호도 조절에 미치는 영향

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Temperature is an essential factor for living organism and profoundly influences various life phenomena such as behavioral pattern, external morphology, cellular metabolism and integrity, and developmental and physiological process. Most animals have abilities to track suitable temperature for surviving and maintaining body temperature (thermotaxis or temperature preference). Thus, it is no wonder that organisms from bacteria to vertebrates have evolved to have a mechanism to sense around temperature and response properly. In a genetic screen for mutants, we found that the histaminergic genes (hdc, hisCl1, and ort) showed abnormal temperature preferences and confirmed using genetic and pharmacological approaches. The histaminergic genes were expressed in the various brain regions including circadian clockworks. The histaminergic mutants showed normal starvation resistance and decrease in mean life span. Interestingly, the histaminergic mutants showed high cold tolerance by low chloride conductance. Also, histamine-administered $w_{1118}$ showed low cold tolerance in a concentrate dependent manner. This suggests that histamine and histamine gated chloride channels could have roles in regulating physiological responses caused by cold stress as well as modulating temperature preferences
Advisors
Kim, Jae-Seobresearcher김재섭researcher
Description
한국과학기술원 : 생명과학과,
Publisher
한국과학기술원
Issue Date
2006
Identifier
254188/325007  / 000995407
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 생명과학과, 2006.2, [ vii, 89 p. ]

Keywords

Drosophila; 온도조절; 온도선호도; 초파리; 히스타민; thermoregulation; temperature preference; Histamine

URI
http://hdl.handle.net/10203/27611
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=254188&flag=dissertation
Appears in Collection
BS-Theses_Ph.D.(박사논문)
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