PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis

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dc.contributor.authorKim, Chang Rokko
dc.contributor.authorNoda, Taichiko
dc.contributor.authorKim, Hyunkyungko
dc.contributor.authorKim, Gibeomko
dc.contributor.authorPark, Seongwanko
dc.contributor.authorNa, Yongwooko
dc.contributor.authorOura, Seiyako
dc.contributor.authorShimada, Keisukeko
dc.contributor.authorBang, Injinko
dc.contributor.authorAhn, Jun-Yeongko
dc.contributor.authorKim, Yong Ryoulko
dc.contributor.authorOh, Se Kyuko
dc.contributor.authorChoi, Hee-Jungko
dc.contributor.authorKim, Jong-Seoko
dc.contributor.authorJung, Inkyungko
dc.contributor.authorLee, Hoko
dc.contributor.authorOkada, Yukiko
dc.contributor.authorIkawa, Masahitoko
dc.contributor.authorBaek, Sung Heeko
dc.date.accessioned2020-09-18T04:01:21Z-
dc.date.available2020-09-18T04:01:21Z-
dc.date.created2020-08-24-
dc.date.created2020-08-24-
dc.date.issued2020-07-
dc.identifier.citationCELL REPORTS, v.32, no.4-
dc.identifier.issn2211-1247-
dc.identifier.urihttp://hdl.handle.net/10203/276107-
dc.description.abstractSpermatogenesis is a complex process of sperm generation, including mitosis, meiosis, and spermiogenesis. During spermiogenesis, histones in post-meiotic spermatids are removed from chromatin and replaced by protamines. Although histone-to-protamine exchange is important for sperm nuclear condensation, the underlying regulatory mechanism is still poorly understood. Here, we identify PHD finger protein 7 (PHF7) as an E3 ubiquitin ligase for histone H3K14 in post-meiotic spermatids. Generation of Phf7-deficient mice and Phf7 C160A knockin mice with impaired E3 ubiquitin ligase activity reveals defects in histone-to-protamine exchange caused by dysregulation of histone removal factor Bromodomain, testis-specific (BRDT) in early condensing spermatids. Surprisingly, E3 ubiquitin ligase activity of PHF7 on histone ubiquitination leads to stabilization of BRDT by attenuating ubiquitination of BRDT. Collectively, our findings identify PHF7 as a critical factor for sperm chromatin condensation and contribute to mechanistic understanding of fundamental phenomenon of histone-to-protamine exchange and potential for drug development for the male reproduction system.-
dc.languageEnglish-
dc.publisherCELL PRESS-
dc.titlePHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis-
dc.typeArticle-
dc.identifier.wosid000555895400006-
dc.identifier.scopusid2-s2.0-85088658801-
dc.type.rimsART-
dc.citation.volume32-
dc.citation.issue4-
dc.citation.publicationnameCELL REPORTS-
dc.identifier.doi10.1016/j.celrep.2020.107950-
dc.contributor.localauthorJung, Inkyung-
dc.contributor.nonIdAuthorKim, Chang Rok-
dc.contributor.nonIdAuthorNoda, Taichi-
dc.contributor.nonIdAuthorKim, Hyunkyung-
dc.contributor.nonIdAuthorKim, Gibeom-
dc.contributor.nonIdAuthorNa, Yongwoo-
dc.contributor.nonIdAuthorOura, Seiya-
dc.contributor.nonIdAuthorShimada, Keisuke-
dc.contributor.nonIdAuthorBang, Injin-
dc.contributor.nonIdAuthorAhn, Jun-Yeong-
dc.contributor.nonIdAuthorKim, Yong Ryoul-
dc.contributor.nonIdAuthorOh, Se Kyu-
dc.contributor.nonIdAuthorChoi, Hee-Jung-
dc.contributor.nonIdAuthorKim, Jong-Seo-
dc.contributor.nonIdAuthorLee, Ho-
dc.contributor.nonIdAuthorOkada, Yuki-
dc.contributor.nonIdAuthorIkawa, Masahito-
dc.contributor.nonIdAuthorBaek, Sung Hee-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordPlusSEX DETERMINATION-
dc.subject.keywordPlusACETYLATION-
dc.subject.keywordPlusBROMODOMAIN-
dc.subject.keywordPlusSPERMATOGENESIS-
dc.subject.keywordPlusDEGRADATION-
dc.subject.keywordPlusINFERTILITY-
dc.subject.keywordPlusRECOGNITION-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordPlusPLATFORM-
dc.subject.keywordPlusPATHWAY-
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