DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Sangsoon | ko |
dc.contributor.author | Artan, Murat | ko |
dc.contributor.author | Han, Seung Hyun | ko |
dc.contributor.author | Park, Hae-Eun H. | ko |
dc.contributor.author | Jung, Yoonji | ko |
dc.contributor.author | Hwang, Ara B. | ko |
dc.contributor.author | Shin, Won Sik | ko |
dc.contributor.author | Kim, Kyong-Tai | ko |
dc.contributor.author | Lee, Seung-Jae, V | ko |
dc.date.accessioned | 2020-08-13T00:55:14Z | - |
dc.date.available | 2020-08-13T00:55:14Z | - |
dc.date.created | 2020-08-05 | - |
dc.date.created | 2020-08-05 | - |
dc.date.created | 2020-08-05 | - |
dc.date.created | 2020-08-05 | - |
dc.date.created | 2020-08-05 | - |
dc.date.issued | 2020-07 | - |
dc.identifier.citation | SCIENCE ADVANCES, v.6, no.27 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | http://hdl.handle.net/10203/275807 | - |
dc.description.abstract | Vaccinia virus-related kinase (VRK) is an evolutionarily conserved nuclear protein kinase. VRK-1, the single Caenorhabditis elegans VRK ortholog, functions in cell division and germline proliferation. However, the role of VRK-1 in postmitotic cells and adult life span remains unknown. Here, we show that VRK-1 increases organismal longevity by activating the cellular energy sensor, AMP-activated protein kinase (AMPK), via direct phosphorylation. We found that overexpression of vrk-1 in the soma of adult C. elegans increased life span and, conversely, inhibition of vrk-1 decreased life span. In addition, vrk-1 was required for longevity conferred by mutations that inhibit C. elegans mitochondria! respiration, which requires AMPK. VRK-1 directly phosphorylated and up-regulated AMPK in both C. elegans and cultured human cells. Thus, our data show that the somatic nuclear kinase, VRK-1, promotes longevity through AMPK activation, and this function appears to be conserved between C. elegans and humans. | - |
dc.language | English | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | VRK-1 extends life span by activation of AMPK via phosphorylation | - |
dc.type | Article | - |
dc.identifier.wosid | 000548735500001 | - |
dc.identifier.scopusid | 2-s2.0-85088428151 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.issue | 27 | - |
dc.citation.publicationname | SCIENCE ADVANCES | - |
dc.identifier.doi | 10.1126/sciadv.aaw7824 | - |
dc.contributor.localauthor | Lee, Seung-Jae, V | - |
dc.contributor.nonIdAuthor | Park, Sangsoon | - |
dc.contributor.nonIdAuthor | Artan, Murat | - |
dc.contributor.nonIdAuthor | Han, Seung Hyun | - |
dc.contributor.nonIdAuthor | Hwang, Ara B. | - |
dc.contributor.nonIdAuthor | Shin, Won Sik | - |
dc.contributor.nonIdAuthor | Kim, Kyong-Tai | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | LONGEVITY | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | EXTENSION | - |
dc.subject.keywordPlus | CRTC-1 | - |
dc.subject.keywordPlus | ROLES | - |
dc.subject.keywordPlus | ROS | - |
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