SPOP modulates transcriptional repression by Daxx = Daxx의 전사 활성 억제에 미치는 SPOP의 영향

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Daxx-mediated transcriptional regulation was modulated by a speckled POZ domain protein SPOP which was first identified as an auto-antigen from the serum of a scleroderma patient. This is the report on the biochemical and functional interactions between Daxx and SPOP. The COOH-terminal region of Daxx interacts with the NH2-terminal region of SPOP. SPOP counteracts Daxx which binds with ETS1 transcription factor to repress the expression of ETS1 responsive gene. We observed that SPOP reverses Daxx-mediated transcriptional repression of MMP1 gene through inhibiting the binding of Daxx with ETS1. Mutagenesis study suggests that the ability of SPOP to self-associate as well as its ability to bind with Daxx is important for the modulation of Daxx-mediated transcriptional repression. This study proposes that SPOP plays an essential role in maintaining the balance between ECM deposition and degradation.
Advisors
Joe, Cheol-Oresearcher조철오researcher
Description
한국과학기술원 : 생명과학과,
Publisher
한국과학기술원
Issue Date
2004
Identifier
240542/325007  / 000995117
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 생명과학과, 2004.8, [ viii, 112 p. ]

Keywords

SPOP

URI
http://hdl.handle.net/10203/27569
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=240542&flag=dissertation
Appears in Collection
BS-Theses_Ph.D.(박사논문)
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