DC Field | Value | Language |
---|---|---|
dc.contributor.author | Umrao, S. | ko |
dc.contributor.author | Maurya, A. K. | ko |
dc.contributor.author | Shukla, V. | ko |
dc.contributor.author | Grigoriev, A. | ko |
dc.contributor.author | Ahuja, R. | ko |
dc.contributor.author | Vinayak, M. | ko |
dc.contributor.author | Srivastava, R. R. | ko |
dc.contributor.author | Saxena, P. S. | ko |
dc.contributor.author | Oh, Il-Kwon | ko |
dc.contributor.author | Srivastava, A. | ko |
dc.date.accessioned | 2020-07-28T04:55:04Z | - |
dc.date.available | 2020-07-28T04:55:04Z | - |
dc.date.created | 2020-07-27 | - |
dc.date.created | 2020-07-27 | - |
dc.date.created | 2020-07-27 | - |
dc.date.issued | 2019-01 | - |
dc.identifier.citation | MATERIALS TODAY BIO, v.1 | - |
dc.identifier.issn | 2590-0064 | - |
dc.identifier.uri | http://hdl.handle.net/10203/275659 | - |
dc.description.abstract | Blue fluorescent hexagonal boron nitride quantum dots (h-BNQDs) of similar to 10 nm size as an effective enhancer for DNA cleavage activity of anticancer drug doxorubicin (DOX) were synthesized using simple one-step hydrothermal disintegration of exfoliated hexagonal boron nitride at very low temperature similar to 120 degrees C. Boron nitride quantum dots ( BNQDs) at a concentration of 25 mu g/ml enhanced DNA cleavage activity of DOX up to 70% as checked by converting supercoiled fragment into nicked circular PBR322 DNA. The interaction of BNQDs with DOX is proportional to the concentration of BNQDs, with binding constant K-b similar to 0.07338 mu g/ml. In addition, ab initio theoretical results indicate that DOX is absorbed on BNQDs at the N-terminated edge with binding energy -1.075 eV and prevented the normal replication mechanisms in DNA. BNQDs have been shown to kill the breast cancer cell MCF-7 extensively as compared with the normal human keratinocyte cell HaCaT. The cytotoxicity of BNQDs may be correlated with reduced reactive oxygen species level and increased apoptosis in MCF-7 cells, which may be liable to enhance the anticancerous activity of DOX. The results provide a base to develop BNQD-DOX as a more effective anticancer drug. | - |
dc.language | English | - |
dc.publisher | ELSEVIER | - |
dc.title | Anticarcinogenic activity of blue fluorescent hexagonal boron nitride quantum dots: as an effective enhancer for DNA cleavage activity of anticancer drug doxorubicin | - |
dc.type | Article | - |
dc.identifier.wosid | 000546326200001 | - |
dc.identifier.scopusid | 2-s2.0-85076065206 | - |
dc.type.rims | ART | - |
dc.citation.volume | 1 | - |
dc.citation.publicationname | MATERIALS TODAY BIO | - |
dc.identifier.doi | 10.1016/j.mtbio.2019.01.001 | - |
dc.contributor.localauthor | Oh, Il-Kwon | - |
dc.contributor.nonIdAuthor | Umrao, S. | - |
dc.contributor.nonIdAuthor | Maurya, A. K. | - |
dc.contributor.nonIdAuthor | Shukla, V. | - |
dc.contributor.nonIdAuthor | Grigoriev, A. | - |
dc.contributor.nonIdAuthor | Ahuja, R. | - |
dc.contributor.nonIdAuthor | Vinayak, M. | - |
dc.contributor.nonIdAuthor | Srivastava, R. R. | - |
dc.contributor.nonIdAuthor | Saxena, P. S. | - |
dc.contributor.nonIdAuthor | Srivastava, A. | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Hydrothermal | - |
dc.subject.keywordAuthor | MCF-7 | - |
dc.subject.keywordAuthor | HaCaT | - |
dc.subject.keywordAuthor | Reduced ROS level | - |
dc.subject.keywordPlus | GRAPHENE OXIDE | - |
dc.subject.keywordPlus | NANOTUBES | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | LUMINESCENCE | - |
dc.subject.keywordPlus | ADRIAMYCIN | - |
dc.subject.keywordPlus | CLEARANCE | - |
dc.subject.keywordPlus | QUERCETIN | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | AGENT | - |
dc.subject.keywordPlus | P53 | - |
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