9.4 MHz A-line rate optical coherence tomography at 1300nm using a wavelength-swept laser based on stretched-pulse active mode-locking

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In optical coherence tomography (OCT), high-speed systems based at 1300nm are among the most broadly used. Here, we present 9.4 MHz A-line rate OCT system at 1300nm. A wavelength-swept laser based on stretched-pulse active mode locking (SPML) provides a continuous and linear-in-wavenumber sweep from 1240nm to 1340nm, and the OCT system using this light source provides a sensitivity of 98dB and a single-sided 6-dB roll-off depth of 2.5mm. We present new capabilities of the 9.4MHz SPML-OCT system in three microscopy applications. First, we demonstrate high quality OCTA imaging at a rate of 1.3 volumes/s. Second, by utilizing its inherent phase stable characteristics, we present wide dynamic range en face Doppler OCT imaging with multiple time intervals ranging from 0.25ms to 2.0ms at a rate of 0.53 volumes/s. Third, we demonstrate video-rate 4D microscopic imaging of a beating Xenopus embryo heart at a rate of 30 volumes/s. This high-speed and high-performance OCT system centered at 1300nm suggests that it can be one of the most promising high-speed OCT platforms enabling a wide range of new scientific research, industrial, and clinical applications at speeds of 10MHz.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2020-06
Language
English
Article Type
Article
Citation

SCIENTIFIC REPORTS, v.10, no.1

ISSN
2045-2322
DOI
10.1038/s41598-020-66322-0
URI
http://hdl.handle.net/10203/275620
Appears in Collection
ME-Journal Papers(저널논문)
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