Blockade of integrin alpha 3 attenuates human pancreatic cancer via inhibition of EGFR signalling

Cited 8 time in webofscience Cited 0 time in scopus
  • Hit : 133
  • Download : 37
The prognosis of pancreatic cancer remains dismal despite continuous and considerable efforts. Integrins (ITGs) are highly expressed in various malignant cancers. However, very few studies investigated the role of integrin alpha 3 (ITG alpha 3) in malignant cancers. Here, we determined the functional role of ITG alpha 3 in pancreatic cancer. Analysis of public microarray databases and Western blot analysis indicated a unique expression of ITG alpha 3 in human pancreatic cancer. Silencing ITG alpha 3 expression significantly inhibited the viability and migration of human pancreatic cancer cells. Notably, ablation of ITG alpha 3 expression resulted in a significant decrease of epidermal growth factor receptor (EGFR) expression compared with transfection of control-siRNA through an increased number of leucine-rich repeats and immunoglobulin-like domain protein 1 (LRIG1) expression. In addition, ablating ITG alpha 3 inhibited tumour growth via blockade of EGFR signalling in vivo. Furthermore, the highly expressed ITG alpha 3 led to a poor prognosis of pancreatic cancer patients. Our results provide novel insights into ITG alpha 3-induced aggressive pancreatic cancer.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2019-02
Language
English
Article Type
Article
Citation

SCIENTIFIC REPORTS, v.9

ISSN
2045-2322
DOI
10.1038/s41598-019-39628-x
URI
http://hdl.handle.net/10203/275517
Appears in Collection
BiS-Journal Papers(저널논문)
Files in This Item
000459698900054.pdf(2.37 MB)Download
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 8 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0