Interferon Response in Hepatitis C Virus-Infected Hepatocytes: Issues to Consider in the Era of Direct-Acting Antivirals

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When interferons (IFNs) bind to their receptors, they upregulate numerous IFN-stimulated genes (ISGs) with antiviral and immune regulatory activities. Hepatitis C virus (HCV) is a single-stranded, positive-sense RNA virus that affects over 71 million people in the global population. Hepatocytes infected with HCV produce types I and III IFNs. These endogenous IFNs upregulate a set of ISGs that negatively impact the outcome of pegylated IFN-alpha and ribavirin treatments, which were previously used to treat HCV. In addition, the IFNL4 genotype was the primary polymorphism responsible for a suboptimal treatment response to pegylated IFN-alpha and ribavirin. However, recently developed direct-acting antivirals have demonstrated a high rate of sustained virological response without pegylated IFN-alpha. Herein, we review recent studies on types I and III IFN responses in HCV-infected hepatocytes. In particular, we focused on open issues related to IFN responses in the direct-acting antiviral era.
Publisher
MDPI
Issue Date
2020-04
Language
English
Article Type
Review
Citation

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.21, no.7

ISSN
1661-6596
DOI
10.3390/ijms21072583
URI
http://hdl.handle.net/10203/274774
Appears in Collection
MSE-Journal Papers(저널논문)
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Interferon-response-in-hepatitis-C-virusinfected-hepatocytes-Issues-to-consider-in-the-era-of-directacting-antivirals2020International-Journal-of-Molecular-SciencesOpen-Access.pdf(1.28 MB)Download

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