Three-dimensional pore network characterization of reconstructed extracellular matrix

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 103
  • Download : 0
The extracellular matrix (ECM) has a fiber network that provides physical scaffolds to cells and plays important roles by regulating cellular functions. Some previous works characterized the mechanical and geometrical properties of the ECM fiber network using reconstituted collagen-I. However, the characterization of the porous structure of reconstituted collagen-I has been limited to the pore diameter measurement, and pore network extraction has not been applied to reconstituted collagen-I despite the importance of pore interconnectivity. Here, we aim to show the importance of characterizing the pore network of reconstituted collagen-I by comparing the pore networks of structures that have different fiber alignments. We show that the fiber alignment significantly changes the pore throat area but not the pore diameter. Also, we demonstrate that larger pore throats are directed in the direction of the fiber alignment, which may help in understanding the enhanced cell migration when fibers are aligned.
Publisher
AMER PHYSICAL SOC
Issue Date
2020-05
Language
English
Article Type
Article
Citation

PHYSICAL REVIEW E, v.101, no.5

ISSN
1539-3755
DOI
10.1103/physreve.101.052414
URI
http://hdl.handle.net/10203/274697
Appears in Collection
ME-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0